Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease.
Airway Remodeling
Airway Resistance
Animals
B-Lymphocytes
/ immunology
Body Weight
Cell Count
Collagen
/ metabolism
Homeodomain Proteins
/ metabolism
Immunity, Innate
Interleukins
/ metabolism
Mice, Inbred C57BL
Pneumonia
/ complications
Pulmonary Alveoli
/ metabolism
Pulmonary Disease, Chronic Obstructive
/ complications
Respiratory Hypersensitivity
T-Lymphocytes
/ immunology
COPD
ILC2s
T cells
emphysema
inflammation
remodelling
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
03
05
2018
revised:
03
08
2018
accepted:
14
08
2018
pubmed:
28
9
2018
medline:
17
10
2019
entrez:
28
9
2018
Statut:
ppublish
Résumé
Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogenesis of COPD are unclear. Therefore, we investigated the roles of T and B lymphocytes and group 2 innate lymphoid cells (ILC2s) in airway inflammation and remodelling, and lung function in an experimental model of COPD using mice that specifically lack these cells (Rag1
Identifiants
pubmed: 30260499
doi: 10.1002/JLB.3AB0518-178R
pmc: PMC6487813
mid: EMS82805
doi:
Substances chimiques
Homeodomain Proteins
0
Interleukins
0
RAG-1 protein
128559-51-3
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
143-150Subventions
Organisme : Wellcome Trust
ID : 100963
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105178805
Pays : United Kingdom
Organisme : MRC UK
ID : U105178805
Pays : International
Organisme : Wellcome Trust
ID : 100963/Z/13/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : U105178805
Pays : United Kingdom
Informations de copyright
©2018 Society for Leukocyte Biology.
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