In vivo microscopic diffusional kurtosis imaging with symmetrized double diffusion encoding EPI.
Algorithms
Animals
Brain
/ diagnostic imaging
Diffusion Tensor Imaging
Echo-Planar Imaging
Image Processing, Computer-Assisted
/ methods
Intravital Microscopy
Male
Models, Statistical
Normal Distribution
Phantoms, Imaging
Probability
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Signal-To-Noise Ratio
diffusional heterogeneity
double diffusion encoding
microscopic DKI
microscopic kurtosis
neurological disorders
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
13
11
2017
revised:
31
05
2018
accepted:
03
06
2018
pubmed:
28
9
2018
medline:
31
12
2019
entrez:
28
9
2018
Statut:
ppublish
Résumé
Diffusional kurtosis imaging (DKI) measures the deviation of the displacement probability from a normal distribution, complementing the data commonly acquired by diffusion MRI. It is important to elucidate the sources of kurtosis contrast, particularly in biological tissues where microscopic kurtosis (intrinsic kurtosis) and diffusional heterogeneity may co-exist. We have developed a technique for microscopic kurtosis MRI, dubbed microscopic diffusional kurtosis imaging (µDKI), using a symmetrized double diffusion encoding (s-DDE) EPI sequence. We compared this newly developed µDKI to conventional DKI methods in both a triple compartment phantom and in vivo. Our results showed that whereas conventional DKI and µDKI provided similar measurements in a compartment of monosphere beads, kurtosis measured by µDKI was significantly less than that measured by conventional DKI in a compartment of mixed Gaussian pools. For in vivo brain imaging, µDKI showed small yet significantly lower kurtosis measurement in regions of the cortex, CSF, and internal capsule compared to the conventional DKI approach. Our study showed that µDKI is less susceptible than conventional DKI to sub-voxel diffusional heterogeneity. Our study also provided important preliminary demonstration of our technique in vivo, warranting future studies to investigate its diagnostic use in examining neurological disorders.
Identifiants
pubmed: 30260504
doi: 10.1002/mrm.27419
pmc: PMC6258297
mid: NIHMS972633
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-541Subventions
Organisme : NINDS NIH HHS
ID : R21 NS085574
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIH HHS
ID : R21NS085574
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS083654
Pays : United States
Organisme : NIH HHS
ID : R01NS083654
Pays : United States
Informations de copyright
© 2018 International Society for Magnetic Resonance in Medicine.
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