Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes.
Acute Disease
Adult
Aged
Biomarkers
/ blood
Cardiovascular Diseases
/ blood
Case-Control Studies
Cell-Derived Microparticles
/ pathology
Diabetes Mellitus, Type 2
/ blood
Diabetic Angiopathies
/ blood
Endothelium, Vascular
/ pathology
Female
Humans
Hypoglycemia
/ blood
Insulin
/ administration & dosage
Male
Middle Aged
endothelial dysfunction
endothelial microparticles
hypoglycaemia
insulin
type 2 diabetes mellitus
Journal
Diabetes, obesity & metabolism
ISSN: 1463-1326
Titre abrégé: Diabetes Obes Metab
Pays: England
ID NLM: 100883645
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
09
08
2018
revised:
24
09
2018
accepted:
25
09
2018
pubmed:
29
9
2018
medline:
6
2
2020
entrez:
29
9
2018
Statut:
ppublish
Résumé
To assess whether endothelial microparticles (EMPs), novel surrogate markers of endothelial injury and dysfunction, are differentially produced in response to acute insulin-induced hypoglycaemia in adults with and without type 2 diabetes. A prospective, parallel study was conducted in individuals with type 2 diabetes (n = 23) and controls (n = 22). Hypoglycaemia (<2.2 mmoL/L: <40 mg/dL) was achieved by intravenous infusion of soluble insulin. Blood samples were collected at baseline and at 0, 30, 60, 120, 240 minutes and 24 hours after hypoglycaemia and analysed for CD31 Following insulin-induced hypoglycaemia, levels of circulating EMPs were maximal at 240 minutes (P < 0.001) and returned to baseline values within 24 hours for both groups. The peak elevations (% rise from 0 minutes following hypoglycaemia) seen in CD31 The associations between peak elevations within 240 minutes after insulin-induced hypoglycaemia for CD31
Substances chimiques
Biomarkers
0
Insulin
0
Types de publication
Controlled Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-540Informations de copyright
© 2018 John Wiley & Sons Ltd.