Adaptation to milking agropastoralism in Chilean goat herders and nutritional benefit of lactase persistence.
Agriculture
Animals
Body Mass Index
Chile
Ethnicity
/ genetics
Evolution, Molecular
Female
Fertility
Gene Frequency
Genetic Association Studies
Goats
Haplotypes
Humans
Lactase
/ genetics
Lactose Intolerance
/ genetics
Male
Milk
Nutritional Physiological Phenomena
Phenotype
Polymorphism, Single Nucleotide
Adaptation
Latin America
body mass index
lactase persistence
natural selection
pastoralism
Journal
Annals of human genetics
ISSN: 1469-1809
Titre abrégé: Ann Hum Genet
Pays: England
ID NLM: 0416661
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
16
03
2018
revised:
05
07
2018
accepted:
06
07
2018
pubmed:
29
9
2018
medline:
20
12
2019
entrez:
29
9
2018
Statut:
ppublish
Résumé
The genetic trait of lactase persistence (LP) evolved as an adaptation to milking pastoralism in the Old World and is a well-known example of positive natural selection in humans. However, the specific mechanisms conferring this selective advantage are unknown. To understand the relationship between milk drinking, LP, growth, reproduction, and survival, communities of the Coquimbo Region in Chile, with recent adoption of milking agropastoralism, were used as a model population. DNA samples and data on stature, reproduction, and diet were collected from 451 participants. Lactose tolerance tests were done on 41 of them. The European -13,910*T (rs4988235) was the only LP causative variant found, showing strong association (99.6%) with LP phenotype. Models of associations of inferred LP status and milk consumption, with fertility, mortality, height, and weight were adjusted with measures of ancestry and relatedness to control for population structure. Although we found no statistically significant effect of LP on fertility, a significant effect (P = 0.002) was observed of LP on body mass index (BMI) in males and of BMI on fertility (P = 0.003). These results fail to support a causal relationship between LP and fertility yet suggest the idea of a nutritional advantage of LP. Furthermore, the proportion of European ancestry around the genetic region of -13,910*T is significantly higher (P = 0.008) than the proportion of European ancestry genome-wide, providing evidence of recent positive selection since European-Amerindian admixture. This signature was absent in nonpastoralist Latin American populations, supporting the hypothesis of specific adaptation to milking agropastoralism in the Coquimbo communities.
Identifiants
pubmed: 30264486
doi: 10.1111/ahg.12277
pmc: PMC6393766
doi:
Substances chimiques
Lactase
EC 3.2.1.108
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-22Subventions
Organisme : UCL Global Engagement fund
Pays : International
Organisme : Wellcome Investigator Award
ID : WT107055AIA
Pays : International
Organisme : Annals of Human Genetics
Pays : International
Organisme : Parkes Foundation
Pays : International
Organisme : Chilean National Commission for Scientific and Technological Research
Pays : International
Organisme : UCL Grand Challenge of Global Health
Pays : International
Organisme : EU Marie Curie ITN FP7 Framework Programme grant, LeCHE, grant
ID : 215362-2
Pays : International
Organisme : Gen Foundation
Pays : International
Informations de copyright
© 2018 The Authors. Annals of Human Genetics published by University College London (UCL) and John Wiley & Sons Ltd.
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