7-Azaindole Analogues as Bioactive Agents and Recent Results.
Angiogenesis Inhibitors
/ chemistry
Animals
Antineoplastic Agents
/ chemistry
Drug Discovery
/ methods
Humans
Indoles
/ chemistry
Melanins
/ agonists
Nicotine
/ agonists
Protein Kinase Inhibitors
/ chemistry
Receptors, CCR2
/ antagonists & inhibitors
Receptors, Immunologic
/ antagonists & inhibitors
Receptors, Prostaglandin
/ antagonists & inhibitors
Azaindole
anti-angiogenic activity
bioactive agents
cytotoxic agents
kinase inhibitor
orai inhibitor.
Journal
Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
05
2017
revised:
18
04
2018
accepted:
27
05
2018
pubmed:
29
9
2018
medline:
25
6
2019
entrez:
29
9
2018
Statut:
ppublish
Résumé
Azaindoles have been accepted as important structures having various biological activities in medicinal chemistry in novel drug discovery. Various azaindole derivatives have been used commercially and newer analogues are synthesized continuously. As in literature, azaindole is a very potent moiety, its derivatives displayed a number of biological activities such as kinase inhibitors, cytotoxic agents, anti-angiogenic activity, CRTh2 receptor antagonists, melanin agonists, nicotine agonists, effectiveness in alzheimer disease, cytokinin analogs, Orai inhibitors in asthma and chemokine receptor- 2 (CCR2) antagonists. This review consists of biological activities of various azaindole analogs, reported so far, and their structure activity relations, along with future perspectives in this field.
Identifiants
pubmed: 30264679
pii: MRMC-EPUB-93300
doi: 10.2174/1389557518666180928154004
doi:
Substances chimiques
7-azaindole dimer
0
Angiogenesis Inhibitors
0
Antineoplastic Agents
0
Indoles
0
Melanins
0
Protein Kinase Inhibitors
0
Receptors, CCR2
0
Receptors, Immunologic
0
Receptors, Prostaglandin
0
Nicotine
6M3C89ZY6R
prostaglandin D2 receptor
XZF106QU24
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
727-736Informations de copyright
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