Cell cluster migration: Connecting experiments with physical models.
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
13
06
2018
revised:
31
07
2018
accepted:
21
09
2018
pubmed:
30
9
2018
medline:
19
5
2020
entrez:
30
9
2018
Statut:
ppublish
Résumé
In multi-cellular organisms, the migration of cohesive clusters of cells containing many individual cells is a common occurrence. Examples include the migration of cells during processes such as the development of the embryo, wound healing, immune response, and the spread of cancer. The migration process depends not only on the traction forces applied by the cluster on its surroundings, in order to move, but also on the viscoelastic properties of both the surrounding matrix and the migrating cellular cluster. Characterizing the viscoelastic properties of the cluster, its environment and the forces within the cluster, in great detail, is difficult both in-vitro and certainly in-vivo. We review here several examples where theoretical studies using simplified models can be used to gain insights into the basic underlying mechanisms that control the cellular migration patterns.
Identifiants
pubmed: 30266687
pii: S1084-9521(18)30147-2
doi: 10.1016/j.semcdb.2018.09.009
pii:
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-86Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.