Herpes simplex virus (HSV) pneumonia in the non-ventilated immunocompromised host: Burden and predictors.
Cytology
Diagnostic algorithm
Herpes simplex virus
Immunodeficiency
Pneumonia
Polymerase chain reaction
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
15
04
2018
revised:
31
07
2018
accepted:
10
09
2018
pubmed:
30
9
2018
medline:
29
5
2020
entrez:
30
9
2018
Statut:
ppublish
Résumé
To evaluate burden and predictors of HSV pneumonia among immunocompromised patients not undergoing invasive mechanical ventilation according to a tailored diagnostic algorithm. This prospective, observational study included immunocompromised adults with pneumonia non-responding to empirical antibiotic therapy. Bronchoalveolar lavage (BAL) specimens were cultured for bacteria, mycobacteria and fungi. Real-time PCR for Herpesviruses and other microorganisms were performed on BAL and other specimens. Cytological examination of BAL samples was carried out for identification of intranuclear inclusion bodies and immunohistochemical staining for HSV. We enrolled 45 patients (mean age 64.6 years) from January 2015 to June 2016. Nineteen (42.2%) cases tested positive for HSV-1 PCR on BAL. According to our definitions, 11 (24.4%) patients had HSV-1 pneumonia with viral loads ranging between 10 HSV pneumonia turned out to be relatively common and should be investigated especially in individuals with HSV positive throat swab and SOT. Interventional studies are needed to assess the real clinical impact of HSV pneumonia in immunocompromised patients.
Identifiants
pubmed: 30267802
pii: S0163-4453(18)30283-4
doi: 10.1016/j.jinf.2018.09.010
pii:
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-133Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.