Approaches, Progress, and Challenges to Hepatitis C Vaccine Development.
HCV
Prophylactic Vaccination
Vaccines
Viral Hepatitis
Journal
Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
15
05
2018
revised:
12
08
2018
accepted:
14
08
2018
pubmed:
1
10
2018
medline:
5
2
2019
entrez:
1
10
2018
Statut:
ppublish
Résumé
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75 million new cases worldwide in 2015. The World Health Organization aims for a 90% reduction in new HCV infections by 2030. An HCV vaccine would prevent transmission, regardless of risk factors, and significantly reduce the global burden of HCV-associated disease. Barriers to development include virus diversity, limited models for testing vaccines, and our incomplete understanding of protective immune responses. Although highly effective vaccines could prevent infection altogether, immune responses that increase the rate of HCV clearance and prevent chronic infection may be sufficient to reduce disease burden. Adjuvant envelope or core protein and virus-vectored nonstructural antigen vaccines have been tested in healthy volunteers who are not at risk for HCV infection; viral vectors encoding nonstructural proteins are the only vaccine strategy to be tested in at-risk individuals. Despite development challenges, a prophylactic vaccine is necessary for global control of HCV.
Identifiants
pubmed: 30268785
pii: S0016-5085(18)35035-2
doi: 10.1053/j.gastro.2018.08.060
pmc: PMC6340767
mid: NIHMS1508110
pii:
doi:
Substances chimiques
Viral Hepatitis Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
418-430Subventions
Organisme : Medical Research Council
ID : MR/K010239/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI077757
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127469
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI088791
Pays : United States
Informations de copyright
Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.
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