Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy.
F-A-85380
Focal epilepsy
Idiopathic generalized epilepsy
Nicotinic receptors
PET
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
21
05
2018
accepted:
18
09
2018
pubmed:
1
10
2018
medline:
8
5
2019
entrez:
1
10
2018
Statut:
ppublish
Résumé
Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [ We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. All patients underwent PET/CT using F-A-85380 and [ In the group of patients with IGE, the voxel-wise and VOI analyses showed a significant increase of F-A-85380 ratio index of binding potential (BP We observed focal changes of density/availability of nicotinic receptors in IGE, namely an increase in the ACC. These data suggest that the modulation of α4β2 nicotinic receptors plays a role not only in ADNFLE, but also in other genetic epileptic syndromes such as IGE and could serve as a biomarker of epilepsy syndromes with a genetic background.
Identifiants
pubmed: 30269157
doi: 10.1007/s00259-018-4175-0
pii: 10.1007/s00259-018-4175-0
doi:
Substances chimiques
Biomarkers
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
385-395Subventions
Organisme : Swiss National Science Foundation
ID : 320030_127608
Pays : Switzerland
Références
Neuron. 2014 Sep 3;83(5):1131-43
pubmed: 25155956
Epilepsia. 2015 Nov;56(11):1803-11
pubmed: 26417846
Cortex. 2015 Apr;65:219-31
pubmed: 25754503
Dev Med Child Neurol. 2014 Jul;56(7):635-41
pubmed: 24650092
J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):159-66
pubmed: 24285321
J Neurosci. 2000 Jan 1;20(1):66-75
pubmed: 10627582
J Neurosci. 2010 Apr 28;30(17):5884-93
pubmed: 20427649
Epilepsy Behav. 2006 Nov;9(3):515-20
pubmed: 16931165
Arch Neurol. 2005 Mar;62(3):371-6
pubmed: 15767501
Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4996-E5005
pubmed: 28584127
Hum Brain Mapp. 2002 Jan;15(1):1-25
pubmed: 11747097
Neurology. 2011 Jan 4;76(1):34-40
pubmed: 21205693
Epilepsia. 2013 Sep;54(9):e138-41
pubmed: 23944956
Brain. 2011 Oct;134(Pt 10):2912-28
pubmed: 21975588
Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S30-45
pubmed: 18228017
Brain. 2013 Oct;136(Pt 10):3004-17
pubmed: 23975517
Nat Protoc. 2007;2(3):499-503
pubmed: 17406613
Eur J Nucl Med Mol Imaging. 2011 Mar;38(3):515-25
pubmed: 21069319
Neurosci Lett. 2018 Feb 22;667:53-65
pubmed: 28216336
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Neurology. 2015 May 5;84(18):e134-6
pubmed: 25941204
J Neurosci. 2007 Jun 13;27(24):6590-9
pubmed: 17567820
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
Semin Cell Dev Biol. 2009 Jun;20(4):432-40
pubmed: 19560048
PLoS Biol. 2008 Dec 23;6(12):2683-97
pubmed: 19108604
Seizure. 2009 Oct;18(8):601-3
pubmed: 19577488
J Nucl Med. 2005 Feb;46(2):240-7
pubmed: 15695782
Mol Pharmacol. 2008 Aug;74(2):348-59
pubmed: 18445710
Epilepsia. 1999 Sep;40(9):1198-209
pubmed: 10487182
Trends Pharmacol Sci. 2015 Feb;36(2):96-108
pubmed: 25639674
J Nucl Med. 2004 Sep;45(9):1458-70
pubmed: 15347712
Eur J Neurosci. 2005 Nov;22(10):2462-74
pubmed: 16307589
Neurology. 2012 May 15;78(20):1555-9
pubmed: 22551729
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
Brain. 1999 Nov;122 ( Pt 11):2101-8
pubmed: 10545395
J Neurosci. 2002 Feb 15;22(4):1480-95
pubmed: 11850474
Epilepsia. 2014 Aug;55(8):1157-69
pubmed: 24938654
Epilepsia. 2014 Jun;55(6):835-40
pubmed: 24702672
J Neurosci. 2017 Oct 4;37(40):9657-9666
pubmed: 28877969
Biol Psychiatry. 2001 Feb 1;49(3):166-74
pubmed: 11230867
Neuroimage. 2010 Jan 1;49(1):80-93
pubmed: 19679190
J Neurosci. 2008 Aug 27;28(35):8756-64
pubmed: 18753377
Neurology. 1996 Nov;47(5):1203-12
pubmed: 8909431
Neuroscience. 1994 Apr;59(3):531-9
pubmed: 8008207
Curr Neuropharmacol. 2018;16(4):403-414
pubmed: 29110618
Eur J Pharmacol. 1993 Apr 6;234(2-3):263-8
pubmed: 8387012
Neuron. 2007 Apr 5;54(1):73-87
pubmed: 17408579
Epilepsia. 2010 Apr;51(4):676-85
pubmed: 20196795
Brain Res. 2007 Dec 14;1185:266-74
pubmed: 17931605
Epilepsy Behav. 2010 Aug;18(4):404-13
pubmed: 20580319
Epilepsia. 2004 Dec;45(12):1568-79
pubmed: 15571515
Arch Gen Psychiatry. 2009 Aug;66(8):866-77
pubmed: 19652126
Epilepsy Res. 2013 Oct;106(3):370-7
pubmed: 23962795
Epilepsia. 2009 Dec;50(12):2538-48
pubmed: 19519798
Neuroimage. 2013 Oct 1;79:42-51
pubmed: 23631995
J Pharmacol Exp Ther. 2010 Nov;335(2):401-8
pubmed: 20688974
J Neurosci Methods. 2016 Feb 15;260:159-74
pubmed: 26068173
Brain. 2006 Aug;129(Pt 8):2047-60
pubmed: 16815873
Dev Sci. 2016 Mar;19(2):284-305
pubmed: 25845529
J Physiol. 2003 Nov 1;552(Pt 3):881-905
pubmed: 12923213
Alzheimer Dis Assoc Disord. 2017 Jan-Mar;31(1):8-12
pubmed: 27680780
Epilepsia. 2003 Sep;44(9):1238-40
pubmed: 12919397
Nature. 2018 May;557(7704):261-265
pubmed: 29720657
Neurosci Lett. 2009 Oct 9;463(3):249-53
pubmed: 19638297
Front Physiol. 2015 Feb 05;6:16
pubmed: 25698972
Epilepsy Res. 2014 Dec;108(10):1740-7
pubmed: 25277883