Novel leptin receptor signaling mutants identify location and sex-dependent modulation of bone density, adiposity, and growth.
Adipocytes, White
/ metabolism
Adiposity
/ physiology
Animals
Bone Density
/ physiology
Cancellous Bone
/ metabolism
Female
Femur
/ metabolism
Leptin
/ genetics
Male
Mice
Mice, Mutant Strains
Mutation
Protein Tyrosine Phosphatase, Non-Receptor Type 11
/ genetics
Receptors, Leptin
/ genetics
Sex Characteristics
Signal Transduction
/ physiology
Spine
/ metabolism
Suppressor of Cytokine Signaling 3 Protein
/ genetics
adipocytes
bone density
bone volume
female
leptin receptor
male
marrow adiposity
obesity
osteoporosis
Journal
Journal of cellular biochemistry
ISSN: 1097-4644
Titre abrégé: J Cell Biochem
Pays: United States
ID NLM: 8205768
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
01
04
2018
accepted:
29
08
2018
pubmed:
1
10
2018
medline:
19
3
2020
entrez:
1
10
2018
Statut:
ppublish
Résumé
Leptin, a hormone primarily produced by adipocytes, contributes to the regulation of bone health by modulating bone density, growth and adiposity. Upon leptin binding, multiple sites of the long form of the leptin receptor (LepRb) are phosphorylated to trigger activation of downstream signaling pathways. To address the role of LepRb-signaling pathways in bone health, we compared the effects of three LepRb mutations on bone density, adiposity, and growth in male and female mice. The ∆65 mutation, which lacks the known tyrosine phosphorylation sites, caused obesity and the most dramatic bone phenotype marked by excessive bone adiposity, osteoporosis, and decreased growth, consistent with the phenotype of db/db and ob/ob mice that fully lack leptin receptor signaling. Mutation of LepRb Tyr
Identifiants
pubmed: 30269370
doi: 10.1002/jcb.27726
pmc: PMC6336499
mid: NIHMS987817
doi:
Substances chimiques
Leptin
0
Receptors, Leptin
0
Socs3 protein, mouse
0
Suppressor of Cytokine Signaling 3 Protein
0
Protein Tyrosine Phosphatase, Non-Receptor Type 11
EC 3.1.3.48
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4398-4408Subventions
Organisme : NIDCR NIH HHS
ID : R00 DE024178
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT007695
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK056731
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101050
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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