Adaptive immunity and IL-17A are not involved in the progression of chronic kidney disease after 5/6 nephrectomy in mice.
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
07
03
2018
revised:
21
08
2018
accepted:
25
08
2018
pubmed:
3
10
2018
medline:
1
8
2020
entrez:
2
10
2018
Statut:
ppublish
Résumé
The adaptive immune response and IL-17A contribute to renal damage in several experimental models of renal injury. To evaluate the role of the adaptive immune response, 5/6 nephrectomy was performed in wildtype DBA/1J mice and in recombination-activating gene-1 (RAG-1) deficient mice that lack B and T-cells. To assess the role of IL-17A, we carried out 5/6 nephrectomy in IL-17A deficient mice. Flow cytometric analysis, immunohistochemistry and RT-PCR were used. Infiltration of CD3 Numbers of CD3 This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
Sections du résumé
BACKGROUND AND PURPOSE
The adaptive immune response and IL-17A contribute to renal damage in several experimental models of renal injury.
EXPERIMENTAL APPROACH
To evaluate the role of the adaptive immune response, 5/6 nephrectomy was performed in wildtype DBA/1J mice and in recombination-activating gene-1 (RAG-1) deficient mice that lack B and T-cells. To assess the role of IL-17A, we carried out 5/6 nephrectomy in IL-17A deficient mice. Flow cytometric analysis, immunohistochemistry and RT-PCR were used.
KEY RESULTS
Infiltration of CD3
CONCLUSIONS AND IMPLICATIONS
Numbers of CD3
LINKED ARTICLES
This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
Identifiants
pubmed: 30270435
doi: 10.1111/bph.14509
pmc: PMC6534810
doi:
Substances chimiques
Il17a protein, mouse
0
Interleukin-17
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2002-2014Informations de copyright
© 2018 The British Pharmacological Society.
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