Recovery Kinetics: Comparison of Patients Undergoing Primary or Revision Procedures for Adult Cervical Deformity Using a Novel Area Under the Curve Methodology.


Journal

Neurosurgery
ISSN: 1524-4040
Titre abrégé: Neurosurgery
Pays: United States
ID NLM: 7802914

Informations de publication

Date de publication:
01 07 2019
Historique:
received: 04 04 2018
accepted: 16 08 2018
pubmed: 3 10 2018
medline: 25 3 2020
entrez: 2 10 2018
Statut: ppublish

Résumé

Limited data are available to objectively define what constitutes a "good" versus a "bad" recovery for operative cervical deformity (CD) patients. Furthermore, the recovery patterns of primary versus revision procedures for CD is poorly understood. To define and compare the recovery profiles of CD patients undergoing primary or revision procedures, utilizing a novel area-under-the-curve normalization methodology. CD patients undergoing primary or revision surgery with baseline to 1-yr health-related quality of life (HRQL) scores were included. Clinical symptoms and HRQL were compared among groups (primary/revision). Normalized HRQL scores at baseline and follow-up intervals (3M, 6M, 1Y) were generated. Normalized HRQLs were plotted and area under the curve was calculated, generating one number describing overall recovery (Integrated Health State). Subanalysis identified recovery patterns through 2-yr follow-up. Eighty-three patients were included (45 primary, 38 revision). Age (61.3 vs 61.9), gender (F: 66.7% vs 63.2%), body mass index (27.7 vs 29.3), Charlson Comorbidity Index, frailty, and osteoporosis (20% vs 13.2%) were similar between groups (P > .05). Primary patients were more preoperatively neurologically symptomatic (55.6% vs 31.6%), less sagittally malaligned (cervical sagittal vertical axis [cSVA]: 32.6 vs 46.6; T1 slope: 28.8 vs 36.8), underwent more anterior-only approaches (28.9% vs 7.9%), and less posterior-only approaches (37.8% vs 60.5%), all P < .05. Combined approaches, decompressions, osteotomies, and construct length were similar between groups (P > .05). Revisions had longer op-times (438.0 vs 734.4 min, P = .008). Following surgery, complication rate was similar between groups (66.6% vs 65.8%, P = .569). Revision patients remained more malaligned (cSVA, TS-CL; P < .05) than primary patients until 1-yr follow-up (P > .05). Normalized HRQLs determined primary patients to exhibit less neck pain (numeric rating scale [NRS]) and myelopathy (modified Japanese Orthopaedic Association) symptoms through 1-yr follow-up compared to revision patients (P < .05). These differences subsided when following patients through 2 yr (P > .05). Despite similar 2-yr HRQL outcomes, revision patients exhibited worse neck pain (NRS) Integrated Health State recovery (P < .05). Despite both primary and revision patients exhibiting similar HRQL outcomes at final follow-up, revision patients were in a greater state of postoperative neck pain for a greater amount of time.

Sections du résumé

BACKGROUND
Limited data are available to objectively define what constitutes a "good" versus a "bad" recovery for operative cervical deformity (CD) patients. Furthermore, the recovery patterns of primary versus revision procedures for CD is poorly understood.
OBJECTIVE
To define and compare the recovery profiles of CD patients undergoing primary or revision procedures, utilizing a novel area-under-the-curve normalization methodology.
METHODS
CD patients undergoing primary or revision surgery with baseline to 1-yr health-related quality of life (HRQL) scores were included. Clinical symptoms and HRQL were compared among groups (primary/revision). Normalized HRQL scores at baseline and follow-up intervals (3M, 6M, 1Y) were generated. Normalized HRQLs were plotted and area under the curve was calculated, generating one number describing overall recovery (Integrated Health State). Subanalysis identified recovery patterns through 2-yr follow-up.
RESULTS
Eighty-three patients were included (45 primary, 38 revision). Age (61.3 vs 61.9), gender (F: 66.7% vs 63.2%), body mass index (27.7 vs 29.3), Charlson Comorbidity Index, frailty, and osteoporosis (20% vs 13.2%) were similar between groups (P > .05). Primary patients were more preoperatively neurologically symptomatic (55.6% vs 31.6%), less sagittally malaligned (cervical sagittal vertical axis [cSVA]: 32.6 vs 46.6; T1 slope: 28.8 vs 36.8), underwent more anterior-only approaches (28.9% vs 7.9%), and less posterior-only approaches (37.8% vs 60.5%), all P < .05. Combined approaches, decompressions, osteotomies, and construct length were similar between groups (P > .05). Revisions had longer op-times (438.0 vs 734.4 min, P = .008). Following surgery, complication rate was similar between groups (66.6% vs 65.8%, P = .569). Revision patients remained more malaligned (cSVA, TS-CL; P < .05) than primary patients until 1-yr follow-up (P > .05). Normalized HRQLs determined primary patients to exhibit less neck pain (numeric rating scale [NRS]) and myelopathy (modified Japanese Orthopaedic Association) symptoms through 1-yr follow-up compared to revision patients (P < .05). These differences subsided when following patients through 2 yr (P > .05). Despite similar 2-yr HRQL outcomes, revision patients exhibited worse neck pain (NRS) Integrated Health State recovery (P < .05).
CONCLUSION
Despite both primary and revision patients exhibiting similar HRQL outcomes at final follow-up, revision patients were in a greater state of postoperative neck pain for a greater amount of time.

Identifiants

pubmed: 30272188
pii: 5110520
doi: 10.1093/neuros/nyy435
doi:

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

E40-E51

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2018 by the Congress of Neurological Surgeons.

Auteurs

Frank A Segreto (FA)

Department of Orthopaedics, NYU Medical Center-Orthopaedic Hospital, New York, New York.

Virginie Lafage (V)

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.

Renaud Lafage (R)

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.

Justin S Smith (JS)

Department of Neurosurgery, University of Virginia Medical Center, Charlottesville, Virginia.

Breton G Line (BG)

Department of Orthopaedic Surgery, Denver International Spine Center, Denver, Colorado.

Robert K Eastlack (RK)

Division of Orthopaedic Surgery, Scripps Clinic, La Jolla, California.

Justin K Scheer (JK)

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois.

Dean Chou (D)

Department of Orthopaedics, University of California, San Francisco, California.

Nicholas J Frangella (NJ)

Department of Orthopaedics, NYU Medical Center-Orthopaedic Hospital, New York, New York.

Samantha R Horn (SR)

Department of Orthopaedics, NYU Medical Center-Orthopaedic Hospital, New York, New York.

Cole A Bortz (CA)

Department of Orthopaedics, NYU Medical Center-Orthopaedic Hospital, New York, New York.

Bassel G Diebo (BG)

Department of Orthopaedics, SUNY Downstate Medical Center, Brooklyn, New York.

Brian J Neuman (BJ)

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Themistocles S Protopsaltis (TS)

Department of Orthopaedics, NYU Medical Center-Orthopaedic Hospital, New York, New York.

Han Jo Kim (HJ)

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.

Eric O Klineberg (EO)

Department of Orthopaedic Surgery, University of California, Davis, Sacramento, California.

Douglas C Burton (DC)

Department of Orthopaedics, University of Kansas Medical Center, Kansas City, Kansas.

Robert A Hart (RA)

Department of Orthopaedics, Swedish Neuroscience Institute, Seattle, Washington.

Frank J Schwab (FJ)

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York.

Shay Bess (S)

Department of Orthopaedic Surgery, Denver International Spine Center, Denver, Colorado.

Christopher I Shaffrey (CI)

Department of Neurosurgery, University of Virginia Medical Center, Charlottesville, Virginia.

Christopher P Ames (CP)

Department of Orthopaedics, University of California, San Francisco, California.

Peter G Passias (PG)

Department of Orthopaedics, NYU Medical Center-Orthopaedic Hospital, New York, New York.

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