Sexual dimorphism in HIV-1 infection.
HIV-1 cure
HIV-1 immunopathology
HIV-1 infection
HIV-1 reservoirs
Sex differences
Sex hormones
Journal
Seminars in immunopathology
ISSN: 1863-2300
Titre abrégé: Semin Immunopathol
Pays: Germany
ID NLM: 101308769
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
03
08
2018
accepted:
28
08
2018
pubmed:
3
10
2018
medline:
3
4
2020
entrez:
3
10
2018
Statut:
ppublish
Résumé
Sex-specific differences affecting various aspects of HIV-1 infection have been reported, including differences in susceptibility to infection, course of HIV-1 disease, and establishment of viral reservoirs. Once infected, initial plasma levels of HIV-1 viremia in women are lower compared to men while the rates of progression to AIDS are similar. Factors contributing to these sex differences are poorly understood, and range from anatomical differences and differential expression of sex hormones to differences in immune responses, the microbiome and socio-economic discrepancies, all of which may impact HIV-1 acquisition and disease progression. Ongoing research efforts aiming at controlling HIV-1 disease or reducing viral reservoirs need to take these sex-based differences in HIV-1 pathogenesis into account. In this review, we discuss established knowledge and recent findings on immune pathways leading to sex differences in HIV-1 disease manifestations, with focus on HIV-1 latency and the effect of female sex hormones on HIV-1.
Identifiants
pubmed: 30276445
doi: 10.1007/s00281-018-0704-y
pii: 10.1007/s00281-018-0704-y
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-202Références
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