A review on anti-adhesion therapies of bacterial diseases.
Adhesins
Anti-adhesion therapy
Antibiotic resistance
Infectious disease
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
21
06
2018
accepted:
14
09
2018
pubmed:
3
10
2018
medline:
17
4
2019
entrez:
3
10
2018
Statut:
ppublish
Résumé
Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most important agent for infection is bacteria attaching to host cells, hence, new techniques and attractive approaches that interfere with the ability of the bacteria to adhere to tissues of the host or detach them from the tissues at the early stages of infection are good therapeutic strategies. All available national and international databanks were searched using the search keywords. Here, we review various approaches to anti-adhesion therapy, including use of receptor and adhesion analogs, dietary constituents, sublethal concentrations of antibiotics, and adhesion-based vaccines. Altogether, the findings suggest that interference with bacterial adhesion serves as a new means to fight infectious diseases. Anti-adhesion-based therapies can be effective in prevention and treatment of bacterial infections, but further work is needed to elucidate underlying mechanisms.
Sections du résumé
BACKGROUND
BACKGROUND
Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most important agent for infection is bacteria attaching to host cells, hence, new techniques and attractive approaches that interfere with the ability of the bacteria to adhere to tissues of the host or detach them from the tissues at the early stages of infection are good therapeutic strategies.
METHODS
METHODS
All available national and international databanks were searched using the search keywords. Here, we review various approaches to anti-adhesion therapy, including use of receptor and adhesion analogs, dietary constituents, sublethal concentrations of antibiotics, and adhesion-based vaccines.
RESULTS
RESULTS
Altogether, the findings suggest that interference with bacterial adhesion serves as a new means to fight infectious diseases.
CONCLUSION
CONCLUSIONS
Anti-adhesion-based therapies can be effective in prevention and treatment of bacterial infections, but further work is needed to elucidate underlying mechanisms.
Identifiants
pubmed: 30276540
doi: 10.1007/s15010-018-1222-5
pii: 10.1007/s15010-018-1222-5
doi:
Substances chimiques
Anti-Infective Agents
0
Bacterial Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-23Commentaires et corrections
Type : ErratumIn
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