Extracellular Vesicles and Insulin Resistance: A Potential Interaction in Vascular Dysfunction.
Insulin
T2DM
endothelium
extracellular vesicles
insulin resistance
vascular.
Journal
Current vascular pharmacology
ISSN: 1875-6212
Titre abrégé: Curr Vasc Pharmacol
Pays: United Arab Emirates
ID NLM: 101157208
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
05
2018
revised:
11
09
2018
accepted:
11
09
2018
pubmed:
3
10
2018
medline:
26
5
2020
entrez:
3
10
2018
Statut:
ppublish
Résumé
Insulin resistance plays a key role in cardiovascular complications associated with diabetes mellitus and hypertensive disorders. In states of insulin resistance several circulating factors may contribute to a defective insulin sensitivity in different tissues, including the vasculature. One of these factors influencing the vascular insulin resistance are the extracellular vesicles. The extracellular vesicles include exosomes, microvesicles, and apoptotic bodies which are released to the circulation by different vascular cells. Since the cargo of extracellular vesicles seems to be altered in metabolic complications associated with insulin resistance, these vesicles may be candidates contributing to vascular insulin resistance. Despite the studies linking insulin resistance signalling pathways with the vascular effect of extracellular vesicles, the involvement of these structures in vascular insulin resistance is a phenomenon that remains unclear.
Identifiants
pubmed: 30277159
pii: CVP-EPUB-93345
doi: 10.2174/1570161116666181002095745
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
491-497Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.