Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
26
02
2018
revised:
31
07
2018
accepted:
19
09
2018
pubmed:
4
10
2018
medline:
7
3
2020
entrez:
4
10
2018
Statut:
ppublish
Résumé
Older patients with melanoma have lower rates of sentinel lymph node (LN) metastases yet paradoxically have inferior survival. Patient age correlated with an inability to retain Technetium radiotracer during sentinel LN biopsy in more than 1,000 patients, and high Technetium counts correlated to better survival. We hypothesized that loss of integrity in the lymphatic vasculature due to extracellular matrix (ECM) degradation might play a role. We have implicated HAPLN1 in age-dependent ECM degradation in the dermis. Here, we queried whether HAPLN1 could be altered in the lymphatic ECM. Lymphatic HAPLN1 expression was prognostic of long-term patient survival. Adding recombinant HAPLN1 to aged fibroblast ECMs
Identifiants
pubmed: 30279172
pii: 2159-8290.CD-18-0168
doi: 10.1158/2159-8290.CD-18-0168
pmc: PMC6328344
mid: NIHMS1508175
doi:
Substances chimiques
Extracellular Matrix Proteins
0
Proteoglycans
0
link protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-95Subventions
Organisme : NCI NIH HHS
ID : K99 CA208012
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA114046
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA174746
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA174523
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207935
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2018 American Association for Cancer Research.
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