Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
26
02
2018
revised:
23
07
2018
accepted:
19
09
2018
pubmed:
4
10
2018
medline:
7
3
2020
entrez:
4
10
2018
Statut:
ppublish
Résumé
Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans, glycoproteins, and cartilage-linking proteins. The most abundantly secreted was HAPLN1, a hyaluronic and proteoglycan link protein. HAPLN1 was lost in aged fibroblasts, resulting in a more aligned ECM that promoted metastasis of melanoma cells. Reconstituting HAPLN1 inhibited metastasis in an aged microenvironment, in 3-D skin reconstruction models, and
Identifiants
pubmed: 30279173
pii: 2159-8290.CD-18-0193
doi: 10.1158/2159-8290.CD-18-0193
pmc: PMC6328333
mid: NIHMS1508200
doi:
Substances chimiques
Extracellular Matrix Proteins
0
Proteoglycans
0
link protein
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-81Subventions
Organisme : NCI NIH HHS
ID : K99 CA208012
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA113451
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA221838
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA114046
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA174746
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211199
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA174523
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207935
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA212437
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA131582
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009171
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA227550
Pays : United States
Organisme : NCI NIH HHS
ID : K00 CA212437
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
©2018 American Association for Cancer Research.
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