Genome-wide association analysis suggests novel loci for Hashimoto's thyroiditis.
Autoimmune thyroid disease
Autoimmunity
GWAS
Genetics
Hashimoto’s thyroiditis
Hypothyroidism
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
10
07
2018
accepted:
18
09
2018
pubmed:
5
10
2018
medline:
21
8
2019
entrez:
5
10
2018
Statut:
ppublish
Résumé
Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we performed the first GWAS followed by replication in a total of 1443 individuals from Croatia. We performed association analysis in a discovery cohort comprising 405 cases and 433 controls. We followed up 13 independent signals (P < 10 We identified three variants suggestively associated with HT: rs12944194 located 206 kb from SDK2 (P = 1.8 × 10 Although discovered loci are implicated with susceptibility to HT for the first time, genomic regions harboring these loci exhibit good biological candidacy due to involvement in the regulation of the thyroid function and autoimmunity. Additionally, we observe genetic overlap between HT and several related traits, such as hypothyroidism, Graves' disease and TPOAb. Our study adds a new knowledge of underlying HT genetics and sets a firm basis for further research.
Identifiants
pubmed: 30284222
doi: 10.1007/s40618-018-0955-4
pii: 10.1007/s40618-018-0955-4
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Pagination
567-576Subventions
Organisme : Hrvatska Zaklada za Znanost
ID : 4950
Organisme : Hrvatska Zaklada za Znanost
ID : 8875
Organisme : Hrvatska Zaklada za Znanost
ID : 1498
Organisme : Ministarstvo Obrazovanja, Znanosti i Sporta
ID : 216-1080315-0302
Organisme : Sixth Framework Programme
ID : LSHG-CT-2006-018947
Organisme : Seventh Framework Programme
ID : 313010
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