NRG1 PLGA MP locally induce macrophage polarisation toward a regenerative phenotype in the heart after acute myocardial infarction.
Animals
Cell Line
Disease Models, Animal
Drug Carriers
/ chemistry
Heart
/ drug effects
Macrophages
/ drug effects
Mice
Mice, Inbred C57BL
Myocardial Infarction
/ drug therapy
Neuregulin-1
/ administration & dosage
Polylactic Acid-Polyglycolic Acid Copolymer
/ chemistry
Recombinant Proteins
/ administration & dosage
Regeneration
Acute myocardial infarction
PLGA
cytokine
heart attack
inflammation
macrophage polarisation
microparticles
neuregulin
tissue repair
Journal
Journal of drug targeting
ISSN: 1029-2330
Titre abrégé: J Drug Target
Pays: England
ID NLM: 9312476
Informations de publication
Date de publication:
Historique:
pubmed:
6
10
2018
medline:
17
7
2020
entrez:
6
10
2018
Statut:
ppublish
Résumé
Neuregulin-1 loaded poly(lactic-co-glycolic acid) (PLGA) microparticles hold great promise for treating acute myocardial infarction, as they have been proved to recover heart function and induce positive heart remodelling in preclinical studies. More recently, the inflammatory response of the heart after acute myocardial infarction (AMI) has been identified as one of the major mechanisms in cardiac tissue remodelling and repair. However, the connection between neuregulin-1 PLGA microparticles and inflammation is still not well characterised. In the present study we assessed this relationship in a mouse AMI model. First, in vitro evidence indicated that neuregulin-1 PLGA microparticles induced a macrophage polarisation toward a regenerative phenotype (CD206
Identifiants
pubmed: 30289743
doi: 10.1080/1061186X.2018.1531417
doi:
Substances chimiques
Drug Carriers
0
NRG1 protein, human
0
Neuregulin-1
0
Recombinant Proteins
0
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM