DOCUMENTATION OF A NEW CHOROIDAL NEVUS.


Journal

Retinal cases & brief reports
ISSN: 1937-1578
Titre abrégé: Retin Cases Brief Rep
Pays: United States
ID NLM: 101298744

Informations de publication

Date de publication:
01 May 2021
Historique:
pubmed: 6 10 2018
medline: 30 10 2021
entrez: 6 10 2018
Statut: ppublish

Résumé

To describe the occurrence of an acquired choroidal nevus in a 73-year-old white man. Case report. A 73-year-old white man was referred for an evaluation and treatment of macular changes in his left eye consistent with pachychoroid neovasculopathy. Baseline funduscopic examination and color fundus photographs showed two small peripheral choroidal nevi in the right eye and a single small choroidal nevus in the far temporal macula of the left eye. Treatment with intravitreal aflibercept was initiated in the left eye on a treat-and-extend dosing regimen. Approximately 1 year later, a new pigmented choroidal lesion was detected in the left macula in an area where previous high-resolution color fundus photographs had shown no abnormal pigmentation. Swept-source optical coherence tomography of the new pigmented lesion showed flat hyperreflectivity within the inner choroid consistent with a small choroidal nevus. The patient was referred to his internist who found no evidence of an occult malignancy. Over the course of more than 4 additional years of continuous follow-up, the new choroidal nevus remained stable, no new fundus abnormalities were detected in either eye, and the patient remained medically stable. To the best of our knowledge, this is the first documented case of a new choroidal nevus. Multimodal imaging performed before lesion detection and over the ensuing 4 years showed its stability, thus allowing for the conclusion that it was a benign choroidal nevus rather than a neoplastic or paraneoplastic process.

Identifiants

pubmed: 30289791
pii: 01271216-202105000-00003
doi: 10.1097/ICB.0000000000000822
doi:

Substances chimiques

Angiogenesis Inhibitors 0
Recombinant Fusion Proteins 0
aflibercept 15C2VL427D
Receptors, Vascular Endothelial Growth Factor EC 2.7.10.1

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

202-206

Références

Gass JD. Problems in the differential diagnosis of choroidal nevi and malignant melanomas. Am J Ophthalmol 1977;83:299–323.
Sumich P, Mitchell P, Wang J. Choroidal nevi in a white population: the blue mountains eye study. Arch Ophthalmol 1998;116:645–650.
Chien JL, Sioufi K, Surakiatchanukul T, et al. Choroidal nevus: a review of prevalence, features, genetics, risks, and outcomes. Curr Opin Ophthalmol 2017;28:228–237.
Shields CL, Furuta M, Berman EL, et al. Choroidal nevus transformation into melanoma: analysis of 2514 consecutive cases. Arch Ophthalmol 2009;127:981–987.
Singh AD, Kalyani P, Topham A. Estimating the risk of malignant transformation of a choroidal nevus. Ophthalmology 2005;112:1784–1789.
Reddy S, Finger PT. Unilateral diffuse uveal melanocytic proliferation (DUMP). Br J Ophthalmol 2007;91:1726–1727.
Pilarski R, Cebulla CM, Massengill JB, et al. Expanding the clinical phenotype of hereditary BAP1 cancer predisposition syndrome, reporting three new cases. Genes Chromosomes Cancer 2014;53:177–182.
Hofmann-Wellenhof R, Marghoob AA, Zalaudek I. Large acquired nevus or dysplastic nevus: what's in the name of a nevus? JAMA Dermatol 2016;152:623–624.

Auteurs

Ravi Parikh (R)

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
Vitreous Retina Macula Consultants of New York, New York, New York.

Orly Gal-Or (O)

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
Vitreous Retina Macula Consultants of New York, New York, New York.
Department of Ophthalmology, Rabin Medical Center, Tel-Aviv, Israel.

Yoichi Sakurada (Y)

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
Vitreous Retina Macula Consultants of New York, New York, New York.
Departments of Ophthalmology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan ; and.

Belinda Leong (B)

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
Vitreous Retina Macula Consultants of New York, New York, New York.

K Bailey Freund (KB)

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York.
Vitreous Retina Macula Consultants of New York, New York, New York.
Department of Ophthalmology, New York University School of Medicine, New York, New York.

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Classifications MeSH