Disrupted functional connectivity and activity in the white matter of the sensorimotor system in patients with pontine strokes.
Adult
Aged
Anisotropy
Biomarkers
/ metabolism
Case-Control Studies
Diffusion Tensor Imaging
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen
/ blood
Pons
/ diagnostic imaging
Prospective Studies
Sensorimotor Cortex
/ diagnostic imaging
Stroke
/ diagnostic imaging
White Matter
/ diagnostic imaging
motor deficit
pontine stroke
sensorimotor system
white matter
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
20
03
2018
accepted:
22
05
2018
pubmed:
7
10
2018
medline:
24
3
2020
entrez:
7
10
2018
Statut:
ppublish
Résumé
White matter (WM) blood oxygenation level-dependent (BOLD) signals are reported to be related to neural activity. However, sensitivity of WM BOLD signals to disease remains unclear. To investigate WM BOLD signal changes, directional variations of resting-state correlations in sensorimotor system in patients with pontine strokes, and to determine the relationship between WM BOLD signals and motor deficits. Prospective. Ethical approval was obtained from the local Ethics Committee and each participant gave written informed consent. Sixteen patients with focal pontine lesions and 16 age-matched control subjects were included. 3.0T T Relevant WM tracts in the sensorimotor system by region of interest-wise analysis were identified. Power spectra of BOLD signals and anisotropy of resting-state correlations were measured in sensorimotor system and compared between two groups. Their relationships with clinical scores were analyzed. Two-sample t-test; partial correlation analysis. Power spectra of BOLD signals in nerve tracts on the ipsilesional side were significantly decreased (P < 0.05). Compared with that in healthy subjects, the anisotropy of resting-state correlations along identified WM tracts was decreased in the thalamus-dorsolateral prefrontal cortex bundle on the contralesional side, and all nerve tracts on the ipsilesional side. Partial least squares regression analysis showed the predicted outcome scores correlated significantly with actual Fugl-Meyer scores (R Our findings suggest that disrupted activity and functional connectivity in WM areas of the sensorimotor system can be detected in pontine strokes, and may serve as a biomarker for motor function prediction. 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:478-486.
Sections du résumé
BACKGROUND
White matter (WM) blood oxygenation level-dependent (BOLD) signals are reported to be related to neural activity. However, sensitivity of WM BOLD signals to disease remains unclear.
PURPOSE
To investigate WM BOLD signal changes, directional variations of resting-state correlations in sensorimotor system in patients with pontine strokes, and to determine the relationship between WM BOLD signals and motor deficits.
STUDY TYPE
Prospective.
SUBJECTS
Ethical approval was obtained from the local Ethics Committee and each participant gave written informed consent. Sixteen patients with focal pontine lesions and 16 age-matched control subjects were included.
FIELD STRENGTH/SEQUENCE
3.0T T
ASSESSMENT
Relevant WM tracts in the sensorimotor system by region of interest-wise analysis were identified. Power spectra of BOLD signals and anisotropy of resting-state correlations were measured in sensorimotor system and compared between two groups. Their relationships with clinical scores were analyzed.
STATISTICAL TESTS
Two-sample t-test; partial correlation analysis.
RESULTS
Power spectra of BOLD signals in nerve tracts on the ipsilesional side were significantly decreased (P < 0.05). Compared with that in healthy subjects, the anisotropy of resting-state correlations along identified WM tracts was decreased in the thalamus-dorsolateral prefrontal cortex bundle on the contralesional side, and all nerve tracts on the ipsilesional side. Partial least squares regression analysis showed the predicted outcome scores correlated significantly with actual Fugl-Meyer scores (R
DATA CONCLUSION
Our findings suggest that disrupted activity and functional connectivity in WM areas of the sensorimotor system can be detected in pontine strokes, and may serve as a biomarker for motor function prediction.
LEVEL OF EVIDENCE
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:478-486.
Substances chimiques
Biomarkers
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
478-486Informations de copyright
© 2018 International Society for Magnetic Resonance in Medicine.