A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.

Gastroenteritis / complications Gastrointestinal Microbiome Humans Inflammatory Bowel Diseases / complications Parkinson Disease / epidemiology
Calprotectin Crohn's disease Inflammatory bowel disease Intestinal inflammation NOD2 Parkinson's disease Short chain fatty acids

Journal

Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583

Informations de publication

Date de publication:
03 2019
Historique:
received: 03 07 2018
revised: 31 08 2018
accepted: 28 09 2018
pubmed: 8 10 2018
medline: 6 5 2020
entrez: 8 10 2018
Statut: ppublish

Résumé

Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease. This overlap provides an opportunity to develop new treatment strategies for at least a subgroup of PD patients.

Identifiants

DOI: 10.1016/j.parkreldis.2018.09.032 PMID: 30292735
pubmed: 30292735
pii: S1353-8020(18)30428-0
doi: 10.1016/j.parkreldis.2018.09.032
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

43-45

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Anouck Becker (A)

Department of Neurology, Saarland University, Homburg, Germany.

Klaus Faßbender (K)

Department of Neurology, Saarland University, Homburg, Germany.

Wolfgang H Oertel (WH)

Department of Neurology, Philipps University Marburg, Germany; Institute for Neurogenomics, Helmholtz Institute, Neuherberg, Germany.

Marcus M Unger (MM)

Department of Neurology, Saarland University, Homburg, Germany. Electronic address: marcus.unger@me.com.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Gastroentérite › A punch in the gut - Intestinal inflammation...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › A punch in the gut - Intestinal inflammation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A punch in the gut - Intestinal inflammation...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › A punch in the gut - Intestinal inflammation...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › A punch in the gut - Intestinal inflammation...