Bisphenol S (BPS) triggers the migration of human non-small cell lung cancer cells via upregulation of TGF-β.
BPS
Migration
NSCLC
Smad-2/3
TGF-β
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
06
08
2018
revised:
28
09
2018
accepted:
03
10
2018
pubmed:
8
10
2018
medline:
15
1
2019
entrez:
8
10
2018
Statut:
ppublish
Résumé
As one of the leading causes of cancer deaths world-wide, the progression of human non-small cell lung cancer (NSCLC) can be regulated by estrogenic signals. Our present data showed that an industrial endocrine disrupting chemical, bisphenol S (BPS), can promote the in vitro migration of NSCLC cells, which was evidenced by the upregulation of vimentin and matrix metalloproteinase-2 (MMP-2). BPS can increase the mRNA and protein expression of IL-10 and TGF-β. While only targeted inhibition of TGF-β can block BPS induced migration of NSCLC cells. The upregulation of TGF-β can further activate the Smad-2/3 pathways. Further, BPS induced expression of TGF-β was ERα/β or G protein-coupled estrogen receptor (GPER) independent, since targeted inhibition of ERα/β or GPER had no effect on BPS induced transcription of TGF-β. We identified that the inhibitor of ERK1/2 can attenuate BPS induced expression of TGF-β and activation of Smad-2/3 pathways. Collectively, we found that nanomolar BPS can trigger the in vitro migration of NSCLC cells via ERK1/2 mediated activation of TGF-β/Smad-2/3 pathways.
Identifiants
pubmed: 30292839
pii: S0887-2333(18)30424-7
doi: 10.1016/j.tiv.2018.10.005
pii:
doi:
Substances chimiques
Phenols
0
Sulfones
0
Transforming Growth Factor beta
0
bis(4-hydroxyphenyl)sulfone
80-09-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
224-231Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.