Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice.
Administration, Intranasal
Animals
Antibodies, Bacterial
/ blood
Atherosclerosis
/ immunology
Chlamydophila Infections
/ immunology
Chlamydophila pneumoniae
/ immunology
Cholesterol
/ blood
Cytokines
/ metabolism
Diet, High-Fat
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Tumor Necrosis Factor, Type I
/ metabolism
Receptors, Tumor Necrosis Factor, Type II
/ genetics
Tumor Necrosis Factor-alpha
/ genetics
Atherosclerosis
Chlamydia pneumoniae
Pathogenesis
Tumor necrosis factor
Tumor necrosis factor receptor 1
Tumor necrosis factor receptor 2
Journal
Microbes and infection
ISSN: 1769-714X
Titre abrégé: Microbes Infect
Pays: France
ID NLM: 100883508
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
15
08
2018
revised:
13
09
2018
accepted:
25
09
2018
pubmed:
8
10
2018
medline:
14
5
2019
entrez:
8
10
2018
Statut:
ppublish
Résumé
The host immune responses that mediate Chlamydia-induced chronic disease sequelae are incompletely understood. The role of TNF-α, TNF receptor 1 (TNFR1), and TNF receptor 2 (TNFR2), in Chlamydia pneumoniae (CPN)-induced atherosclerosis was studied using the high-fat diet-fed male C57BL/6J mouse model. Following intranasal CPN infection, TNF-α knockout (KO), TNFR1 KO, TNFR2 KO, and TNFR 1/2 double-knockout, displayed comparable serum anti-chlamydial antibody response, splenic antigen-specific cytokine response, and serum cholesterol profiles compared to wild type (WT) animals. However, atherosclerotic pathology in each CPN-infected KO mouse group was reduced significantly compared to WT mice, suggesting that both TNFR1 and TNFR2 promote CPN-induced atherosclerosis.
Identifiants
pubmed: 30292879
pii: S1286-4579(18)30152-7
doi: 10.1016/j.micinf.2018.09.003
pmc: PMC6445723
mid: NIHMS1508839
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Cytokines
0
Receptors, Tumor Necrosis Factor, Type I
0
Receptors, Tumor Necrosis Factor, Type II
0
Tnf protein, mouse
0
Tnfrsf1a protein, mouse
0
Tumor Necrosis Factor-alpha
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-108Subventions
Organisme : NIAID NIH HHS
ID : R15 AI101920
Pays : United States
Informations de copyright
Copyright © 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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