Fourier transform infrared spectroscopy based spectral biomarkers of metastasized breast cancer progression.
3D in vitro model
Bone metastases
Breast cancer
FTIR spectroscopy
Principal component analysis
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
05 Feb 2019
05 Feb 2019
Historique:
received:
06
08
2018
revised:
28
09
2018
accepted:
29
09
2018
pubmed:
8
10
2018
medline:
12
12
2018
entrez:
8
10
2018
Statut:
ppublish
Résumé
Breast cancer is a global health issue and the second leading cause of cancer death in women. Breast cancer tends to migrate to bone and causes bone metastases which is ultimately the cause of death. Here, we report the use of FTIR to identify spectral biomarkers of cancer progression on 3D in vitro model of breast cancer bone metastasis. Our results indicate that the following spectral biomarkers can monitor cancer progression, for example, lipids (CH2 asymmetric/CH2 symmetric stretch), Amide I/Amide II, and RNA/DNA. Principal component analysis also confirmed the involvement of protein, lipids and nucleic acids in cancer progression on sequential culture. The collective observations from this study suggest successful application of FTIR as a non-invasive and accurate method to identify biochemical changes in cancer cells during the progression of breast cancer bone metastasis.
Identifiants
pubmed: 30292907
pii: S1386-1425(18)30906-5
doi: 10.1016/j.saa.2018.09.052
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-96Informations de copyright
Copyright © 2018. Published by Elsevier B.V.