Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma.
Airway inflammation
Asthma
Epoxide hydrolase 1 (EPHX1)
Oxidative stress
Polycyclic aromatic hydrocarbons (PAHs)
Journal
Environmental geochemistry and health
ISSN: 1573-2983
Titre abrégé: Environ Geochem Health
Pays: Netherlands
ID NLM: 8903118
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
30
12
2017
accepted:
29
09
2018
pubmed:
8
10
2018
medline:
29
5
2019
entrez:
8
10
2018
Statut:
ppublish
Résumé
Asthma, as one of the most common chronic diseases in children and adults, is a consequence of complex gene-environment interactions. Polycyclic aromatic hydrocarbons (PAHs), as a group of widespread environmental organic pollutants, are involved in the development, triggering and pathologic changes of asthma. Various previous studies reported the critical roles of PAHs in immune changes, oxidative stress and environment-gene interactions of asthma. EPHX1 (the gene of epoxide hydrolase 1, an enzyme mediating human PAH metabolism) had a possible association with asthma by influencing PAH metabolism. This review summarized that (1) the roles of PAHs in asthma-work as risk factors; (2) the possible mechanisms involved in PAH-related asthma-through immunologic and oxidative stress changes; (3) the interactions between PAHs and EPHX1 involved in asthma-enzymatic activity of epoxide hydrolase 1, which affected by EPHX1 genotypes/SNPs/diplotypes, could influence human PAH metabolism and people's vulnerability to PAH exposure. This review provided a better understanding of the above interactions and underlying mechanisms for asthma which help to raise public's concern on PAH control and develop strategies for individual asthma primary prevention.
Identifiants
pubmed: 30293161
doi: 10.1007/s10653-018-0201-1
pii: 10.1007/s10653-018-0201-1
doi:
Substances chimiques
Polycyclic Aromatic Hydrocarbons
0
Epoxide Hydrolases
EC 3.3.2.-
EPHX1 protein, human
EC 3.3.2.9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-210Subventions
Organisme : National Natural Science Foundation of China
ID : 21876065
Organisme : Department of Education of Guangdong Government Top-tier University Development Scheme for Research and Control of Infectious Diseases
ID : 2016046
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