Massive bone marrow necrosis revealing an HIV-related primary bone marrow lymphoma: a diagnostic challenge.
Bone marrow necrosis (BMN)
Diffuse large B-cell lymphoma (DLBCL)
Dismal prognosis
Human immunodeficiency virus (HIV)
Primary bone marrow lymphoma
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
25
06
2018
accepted:
01
10
2018
revised:
28
09
2018
pubmed:
8
10
2018
medline:
7
2
2019
entrez:
8
10
2018
Statut:
ppublish
Résumé
Bone marrow necrosis (BMN) is a condition that can be difficult to diagnose, requiring a hematologist experienced in bone marrow morphology. This diagnostic challenge should alert the clinician of a severe disease or a possible underlying malignancy, either hematological or a solid tumor. We describe the concomitant presence of a primary bone marrow lymphoma (diffuse large B-cell lymphoma-DLBCL), along with an extensive BMN in an HIV patient for the first time in a living individual. HIV infection, BMN and DLBCL presented a multifactorial crossword of molecular events underlying the complex pathophysiology. The exact precipitating pathophysiological events resulting in BMN remain obscure and provide their clear impact for future research. The present report is instructive and also contains a critical review of the literature related to the case presented.
Identifiants
pubmed: 30293217
doi: 10.1007/s12185-018-2542-z
pii: 10.1007/s12185-018-2542-z
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-129Références
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