Rubidium-82 positron emission tomography for detection of acute doxorubicin-induced cardiac effects in lymphoma patients.
Adolescent
Adult
Aged
Aged, 80 and over
Antibiotics, Antineoplastic
/ adverse effects
Cardiotoxicity
/ diagnostic imaging
Doxorubicin
/ adverse effects
Female
Humans
Lymphoma
/ drug therapy
Male
Middle Aged
Myocardial Perfusion Imaging
Positron-Emission Tomography
Predictive Value of Tests
Prospective Studies
Rubidium Radioisotopes
Young Adult
Journal
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN: 1532-6551
Titre abrégé: J Nucl Cardiol
Pays: United States
ID NLM: 9423534
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
30
07
2018
accepted:
05
09
2018
pubmed:
10
10
2018
medline:
23
11
2021
entrez:
10
10
2018
Statut:
ppublish
Résumé
Doxorubicin is a cornerstone in lymphoma treatment, but is limited by dose-dependent cardiotoxicity. Rubidium-82 positron emission tomography ( We included 70 lymphoma patients scheduled for doxorubicin-based treatment. Cardiotoxicity was evaluated with Decreases in MPR after initial doxorubicin exposure in lymphoma patients may represent an early marker of doxorubicin-induced cardiotoxicity. The prognostic value of acute doxorubicin-induced changes in MPR remains to be investigated.
Sections du résumé
BACKGROUND
Doxorubicin is a cornerstone in lymphoma treatment, but is limited by dose-dependent cardiotoxicity. Rubidium-82 positron emission tomography (
METHODS AND RESULTS
We included 70 lymphoma patients scheduled for doxorubicin-based treatment. Cardiotoxicity was evaluated with
CONCLUSION
Decreases in MPR after initial doxorubicin exposure in lymphoma patients may represent an early marker of doxorubicin-induced cardiotoxicity. The prognostic value of acute doxorubicin-induced changes in MPR remains to be investigated.
Identifiants
pubmed: 30298372
doi: 10.1007/s12350-018-1458-6
pii: 10.1007/s12350-018-1458-6
doi:
Substances chimiques
Antibiotics, Antineoplastic
0
Rubidium Radioisotopes
0
Doxorubicin
80168379AG
Rubidium-82
9K730EL8KU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1698-1707Commentaires et corrections
Type : CommentIn