Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.

Acid Ceramidase Animals Antioxidants / pharmacology Cholesterol / metabolism Diet, High-Fat Dietary Supplements Disease Models, Animal Disease Progression Fatty Liver / metabolism Fibrosis / drug therapy Inflammation / drug therapy Insulin Resistance Lipid Metabolism Liver / drug effects Male Mice Mice, Inbred C57BL Mice, Knockout Non-alcoholic Fatty Liver Disease / metabolism Obesity / metabolism Oxidative Stress / drug effects Phosphatidylethanolamine N-Methyltransferase / genetics Phosphotransferases (Alcohol Group Acceptor) RNA, Messenger Vitamin E / administration & dosage
Antioxidant Ceramide Non-alcoholic fatty liver disease Oxidative stress Phosphatidylcholine Vitamin E

Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 2019
Historique:
received: 29 05 2018
revised: 27 09 2018
accepted: 05 10 2018
pubmed: 10 10 2018
medline: 14 8 2019
entrez: 10 10 2018
Statut: ppublish

Résumé

Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Pemt

Identifiants

DOI: 10.1016/j.bbadis.2018.10.010 PMID: 30300671
pubmed: 30300671
pii: S0925-4439(18)30387-9
doi: 10.1016/j.bbadis.2018.10.010
pii:
doi:

Substances chimiques

Antioxidants 0
RNA, Messenger 0
Vitamin E 1406-18-4
Cholesterol 97C5T2UQ7J
PEMT protein, mouse EC 2.1.1.17
Phosphatidylethanolamine N-Methyltransferase EC 2.1.1.17
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
ceramide kinase EC 2.7.1.138
Acid Ceramidase EC 3.5.1.23
Asah1 protein, mouse EC 3.5.1.23

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

14-25

Subventions

Organisme : CIHR
ID : MOP 5182
Pays : Canada

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Natalia Presa (N)

Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48980 Bilbao, Spain.

Robin D Clugston (RD)

Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada; Department of Physiology, University of Alberta, Edmonton, AB, Canada.

Susanne Lingrell (S)

Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.

Samuel E Kelly (SE)

School of Biological Sciences and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30338, USA.

Alfred H Merrill (AH)

School of Biological Sciences and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30338, USA.

Sayantan Jana (S)

Department of Physiology, University of Alberta, Edmonton, AB, Canada.

Zamaneh Kassiri (Z)

Department of Physiology, University of Alberta, Edmonton, AB, Canada.

Antonio Gómez-Muñoz (A)

Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48980 Bilbao, Spain.

Dennis E Vance (DE)

Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.

Rene L Jacobs (RL)

Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada; Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada.

Jelske N van der Veen (JN)

Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB, Canada; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada. Electronic address: jelske@ualberta.ca.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Ceramidases › Acid Ceramidase › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Eucaryotes › Animaux › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Système digestif › Foie › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Phosphatidylethanolamine N-methyltransferase › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Vitamin E alleviates non-alcoholic fatty liver...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Vitamin E alleviates non-alcoholic fatty liver...