Squalene-PEG: Pyropheophorbide-a nanoconstructs for tumor theranostics.
Animals
Apoptosis
Cell Proliferation
Chick Embryo
Chlorophyll
/ analogs & derivatives
Chorioallantoic Membrane
/ drug effects
Drug Delivery Systems
Female
Glioblastoma
/ drug therapy
Humans
Light
Male
Mice
Nanoparticles
/ administration & dosage
Photochemotherapy
Photosensitizing Agents
/ administration & dosage
Polyethylene Glycols
/ chemistry
Prostatic Neoplasms
/ drug therapy
Squalene
/ administration & dosage
Theranostic Nanomedicine
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Fluorescence photodiagnosis
Nanoconstructs
Photodynamic therapy
Pyropheophorbide-a
Self-assembly
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
20
02
2018
revised:
11
09
2018
accepted:
24
09
2018
pubmed:
12
10
2018
medline:
6
2
2019
entrez:
11
10
2018
Statut:
ppublish
Résumé
Novel nanoscale drug delivery biomaterials are of great importance for the diagnosis and treatment of different cancers. We have developed a new pegylated squalene (SQ-PEG) derivative with self-assembly properties. Supramolecular assembly with a lipophilic photosensitizer pyropheophorbide-a (Ppa) by nanoprecipitation gave nanoconstructs SQ-PEG:Ppa with an average size of 200 nm in diameter and a drug loading of 18% (w/w). The composite material demonstrates nanoscale optical properties by tight packing of Ppa within Sq-PEG:Ppa resulting in 99.99% fluorescence self-quenching. The biocompatibility of the nanomaterial and cell phototoxicity under light irradiation were investigated on PC3 prostate tumor cells in vitro. SQ-PEG:Ppa showed excellent phototoxic effect at low light dose of 5.0 J/cm
Identifiants
pubmed: 30304701
pii: S1549-9634(18)30532-X
doi: 10.1016/j.nano.2018.09.013
pii:
doi:
Substances chimiques
Photosensitizing Agents
0
Chlorophyll
1406-65-1
pyropheophorbide a
24533-72-0
Polyethylene Glycols
3WJQ0SDW1A
Squalene
7QWM220FJH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
243-251Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.