Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke.
Adipose Tissue
/ metabolism
Animals
Biocompatible Materials
/ chemistry
Brain
/ metabolism
Cell Proliferation
/ drug effects
Cerebral Arteries
/ drug effects
Endothelial Cells
/ metabolism
Humans
Hyaluronic Acid
/ chemistry
Mice, Nude
Models, Animal
Neural Stem Cells
/ metabolism
Neurogenesis
Neurons
/ metabolism
Porosity
Stroke
/ drug therapy
Surface Properties
Thrombosis
/ drug therapy
Tissue Engineering
Tissue Scaffolds
/ chemistry
adipose stem cells
biomaterials
cell therapy
hyaluronic acid
stroke
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
19
06
2018
revised:
23
08
2018
accepted:
08
09
2018
pubmed:
12
10
2018
medline:
23
9
2020
entrez:
12
10
2018
Statut:
ppublish
Résumé
Endogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds made of hyaluronic acid (HA) biomaterials (BM) could provide a suitable environment to home not only new neurons, but also vessels, glia and neurofilaments. Further, the addition of exogenous cells, such as adipose stem cells (ASC) could increase this effect. Athymic mice were randomly assigned to a one of four group: stroke alone, stroke and implantation of BM, stroke and implantation of BM with ASC, and sham operated animals. Stroke model consisted of middle cerebral artery thrombosis with FeCl
Substances chimiques
Biocompatible Materials
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1598-1606Subventions
Organisme : CIBER BBN
Pays : International
Organisme : ERANET NEURON CALL
ID : PRI-PIMNEU-2011-1372
Pays : International
Organisme : Spanish Science & Innovation Ministery
ID : MAT 2011- 28791-C03-01
Pays : International
Organisme : Spanish Science & Innovation Ministery
ID : MAT 2011- 28791-C03-02 an
Pays : International
Organisme : TERCEL
ID : RD12/0019/0010
Pays : International
Organisme : Spanish Ministry of Economy and Competitiveness
ID : MAT2015-66666-C3
Pays : International
Organisme : Spanish Ministry of Economy and Competitiveness
ID : DPI2015-72863-EXP
Pays : International
Informations de copyright
© 2018 Wiley Periodicals, Inc.