Enhanced gastrointestinal passive paracellular permeability contributes to the obesity-associated hyperoxaluria.
gastrointestinal paracellular permeability
hyperoxaluria
inflammation
intestinal oxalate absorption
obesity
oxidative stress
tight junction proteins
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
pubmed:
12
10
2018
medline:
20
11
2019
entrez:
12
10
2018
Statut:
ppublish
Résumé
Most kidney stones (KS) are composed of calcium oxalate and small increases in urine oxalate enhance the stone risk. Obesity is a risk factor for KS, and urinary oxalate excretion increases with increased body size. We previously established the obese ob/ob ( ob) mice as a model (3.3-fold higher urine oxalate) to define the pathogenesis of obesity-associated hyperoxaluria (OAH). The purpose of this study was to test the hypothesis that the obesity-associated enhanced small intestinal paracellular permeability contributes to OAH by increasing passive paracellular intestinal oxalate absorption. ob Mice have significantly higher jejunal (1.6-fold) and ileal (1.4-fold) paracellular oxalate absorption ex vivo and significantly higher (5-fold) urine [
Identifiants
pubmed: 30307745
doi: 10.1152/ajpgi.00266.2018
pmc: PMC6383380
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
G1-G14Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK042086
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101643
Pays : United States
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