The Prevalence of Gastroesophageal Reflux in Patients With Excessive Central Airway Collapse.
Bronchoscopy
/ methods
Comorbidity
Esophageal pH Monitoring
/ methods
Female
Gastroesophageal Reflux
/ diagnosis
Humans
Male
Middle Aged
Prevalence
Respiratory System
/ pathology
Retrospective Studies
Severity of Illness Index
Tomography, X-Ray Computed
/ methods
Tracheobronchomalacia
/ diagnosis
United States
/ epidemiology
excessive central airway collapse
excessive dynamic airway collapse
gastroesophageal reflux
tracheobronchomalacia
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
09
04
2018
revised:
10
09
2018
accepted:
24
09
2018
pubmed:
13
10
2018
medline:
21
12
2019
entrez:
13
10
2018
Statut:
ppublish
Résumé
Gastroesophageal reflux (GER) is increasingly recognized as an exacerbating or causal factor in several respiratory diseases. There is a high prevalence of GER in infants with airway malacia. However, such data are lacking in adults. This retrospective study was conducted to determine the relationship between GER and excessive central airway collapse (ECAC). The study included consecutive patients with ECAC referred to the Complex Airway Center at Beth Israel Deaconess Medical Center who underwent esophageal pH testing for GER between July 2014 and June 2018. Sixty-three of 139 patients with ECAC (45.3%) had documented GER as shown by an abnormal esophageal pH test result. The mean DeMeester score was 32.2, with a symptom association probability of 39.7% of GER-positive patients. Twenty-nine of 63 patients (46%) with GER reported improvement in respiratory symptoms following maximal medical therapy or antireflux surgery without requiring further treatment for ECAC. GER is prevalent among patients with ECAC, and aggressive reflux treatment should be considered in these patients prior to considering invasive airway procedures or surgery.
Sections du résumé
BACKGROUND
Gastroesophageal reflux (GER) is increasingly recognized as an exacerbating or causal factor in several respiratory diseases. There is a high prevalence of GER in infants with airway malacia. However, such data are lacking in adults.
METHODS
This retrospective study was conducted to determine the relationship between GER and excessive central airway collapse (ECAC). The study included consecutive patients with ECAC referred to the Complex Airway Center at Beth Israel Deaconess Medical Center who underwent esophageal pH testing for GER between July 2014 and June 2018.
RESULTS
Sixty-three of 139 patients with ECAC (45.3%) had documented GER as shown by an abnormal esophageal pH test result. The mean DeMeester score was 32.2, with a symptom association probability of 39.7% of GER-positive patients. Twenty-nine of 63 patients (46%) with GER reported improvement in respiratory symptoms following maximal medical therapy or antireflux surgery without requiring further treatment for ECAC.
CONCLUSIONS
GER is prevalent among patients with ECAC, and aggressive reflux treatment should be considered in these patients prior to considering invasive airway procedures or surgery.
Identifiants
pubmed: 30312588
pii: S0012-3692(18)32561-3
doi: 10.1016/j.chest.2018.09.021
pmc: PMC6435905
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
540-545Informations de copyright
Copyright © 2018. Published by Elsevier Inc.
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