Topical nanodelivery system of lutein for the prevention of selenite-induced cataract.
Administration, Oral
Administration, Topical
Animals
Cataract
/ chemically induced
Drug Delivery Systems
Female
Lens, Crystalline
/ drug effects
Lutein
/ administration & dosage
Nanoparticles
/ administration & dosage
Oxidative Stress
/ drug effects
Rats
Selenious Acid
/ toxicity
Trace Elements
/ toxicity
Cataract
Lutein
Nanocarrier
Poly(lactic-co-glycolic acid)
Zein
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
19
06
2018
revised:
04
09
2018
accepted:
17
09
2018
pubmed:
13
10
2018
medline:
6
2
2019
entrez:
13
10
2018
Statut:
ppublish
Résumé
Cataracts are responsible for half of the world blindness, surgery being the only viable treatment. Lutein, a naturally occurring carotenoid in the eye, has the potential to reduce cataract progression by protecting the eye from photo-oxidative stress. To restore the eye's natural line of defense against photo-oxidative stress, a formulation was developed using zein and poly(lactic-co-glycolic acid) nanoparticles (NPs) embedded in an optimized bioadhesive thermosensitive gel for the delivery of lutein via topical application. Cataracts were induced in Crl:WI rats via selenite injection at 13 days post-partum, followed by 7 days of treatment with free lutein or lutein-loaded NPs administered orally or topically. Cataract severity was significantly reduced in rats treated with topical applications of lutein-loaded NPs compared to the positive control, while no significant differences were observed in rats treated with other lutein formulations including oral and topically applied free lutein.
Identifiants
pubmed: 30312662
pii: S1549-9634(18)30535-5
doi: 10.1016/j.nano.2018.09.016
pii:
doi:
Substances chimiques
Trace Elements
0
Selenious Acid
F6A27P4Q4R
Lutein
X72A60C9MT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-197Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.