Effect of Dosing Cup Size on the Aerosol Performance of High-Dose Carrier-Based Formulations in a Novel Dry Powder Inhaler.
aerosol performance
carrier formulation
dosing cup size
impaction forces
reservoir-based dry powder inhaler
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
20
07
2018
revised:
27
09
2018
accepted:
28
09
2018
pubmed:
13
10
2018
medline:
14
5
2020
entrez:
13
10
2018
Statut:
ppublish
Résumé
This study investigated how varying the dosing cup size of a novel reservoir dry powder inhaler (DPI) affects the detachment of a micronized active pharmaceutical ingredient from larger carrier particles, and the aerosol performance of a DPI carrier formulation. Three different-sized dosing cups were designed: 3D printed with cup volumes of 16.26 mm
Identifiants
pubmed: 30312722
pii: S0022-3549(18)30594-X
doi: 10.1016/j.xphs.2018.09.033
pii:
doi:
Substances chimiques
Aerosols
0
Anti-Asthmatic Agents
0
Beclomethasone
KGZ1SLC28Z
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
949-959Informations de copyright
Copyright © 2019 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.