Enucleation in Asian Indian patients: a histopathological review of 2009 cases.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
21
06
2018
accepted:
28
06
2018
pubmed:
14
10
2018
medline:
18
5
2019
entrez:
14
10
2018
Statut:
ppublish
Résumé
To review the indications of enucleation in Asian Indian patients and study the trend over the 22-year period. Retrospective study of 2009 patients who underwent enucleation. The mean age at presentation of patients who underwent enucleation was 155 months The histopathology diagnosis included a benign tumor (n = 22, 1%), malignant tumor (n = 1472, 73%), acute trauma (n = 93, 5%), retinal vascular disease (n = 50, 3%), inflammatory/infective pathology (n = 33, 2%), or other miscellaneous/non-specific diagnosis (n = 460, 23%). There was a good correlation between the clinical and histopathology diagnoses at 96%. The most common indication for enucleation in young patients ( ≤ 20 years) was retinoblastoma (n = 1257, 82%; p < 0.001), atrophic bulbi or phthisis bulbi (n = 163, 39%; p < 0.001) in middle-age adults, and uveal melanoma (n = 25, 42%; p < 0.001) in older adults. Over the years, there was a decreasing trend of enucleations for atrophic bulbi/phthisis bulbi/painful blind eye (33% from the years 1996 through 2000 to 7% from 2010 to 2018; p < 0.001) and acute trauma (3% from the years 1996 through 2000 to < 1% from 2010 to 2018; p < 0.001) and an increasing trend for intraocular tumors including retinoblastoma (56% from the years 1996 through 2000 to 73% from 2010 to 2018; p = 0.01) and uveal melanoma (3% from the years 1996 through 2000 to 11% from 2010 to 2018; p < 0.006). In Asian Indian population, malignant tumors remain the most common indication for enucleation in young and older patients, while desire for better cosmesis with customized ocular prosthesis is the main indication for enucleation in middle-age adults. 摘要: 目的: 通过回顾亚洲印度地区的眼球摘除术适应症, 研究眼球摘除术适应症未来22年的发展趋势。方法: 回顾性分析2009例行眼球摘除术的患者。结果: 眼球摘除术患者平均年龄155个月, 病理组织学诊断包括良性肿瘤(n=22, 1%)、恶性肿瘤(n=1472, 73%)、急性创伤(n=93, 5%)、视网膜血管疾病(n=50, 3%)、炎症/感染病理(n=33, 2%)或其他混杂/非特异性诊断(n=460,23%)。96%的患者临床诊断与病理组织学诊断有较好的相关性。年轻患者(≤20岁)最常见的眼球摘除术适应症是视网膜母细胞瘤(n=1257, 82%;p < 0.001);中年人常见的眼球摘除术适应症是眼球萎缩或眼结核(n=163,39%;p < 0.001);老年人常见的眼球摘除术适应症是葡萄膜黑色素瘤(n=25,42%;p < 0.001)。近年来, 眼球萎缩/眼结核/疼痛性失明行眼球摘除术者 (1996年-2000年 33%, 2010年-2018年7%)和急性创伤行眼球摘除术者(1996年-2000年3%, 2010年-2018年<1%;p < 0.001)均呈现下降趋势。而眼内肿瘤行眼球摘除术者呈上升趋势, 其包括视网膜母细胞瘤(1996年-2000年 56%, 2010年-2018年 73%;p=0.01)和葡萄膜黑色素瘤(1996年-2000年3%, 2010年-2018年11%;p < 0.006)。结论:在亚洲印度地区人群中, 恶性肿瘤仍然是青年和老年患者行眼球摘除术最常见的适应症, 而对个性化眼球假体更好的晶状体形态的渴望是中老年人行眼球摘除术的主要指征。.
Autres résumés
Type: Publisher
(chi)
摘要: 目的: 通过回顾亚洲印度地区的眼球摘除术适应症, 研究眼球摘除术适应症未来22年的发展趋势。方法: 回顾性分析2009例行眼球摘除术的患者。结果: 眼球摘除术患者平均年龄155个月, 病理组织学诊断包括良性肿瘤(n=22, 1%)、恶性肿瘤(n=1472, 73%)、急性创伤(n=93, 5%)、视网膜血管疾病(n=50, 3%)、炎症/感染病理(n=33, 2%)或其他混杂/非特异性诊断(n=460,23%)。96%的患者临床诊断与病理组织学诊断有较好的相关性。年轻患者(≤20岁)最常见的眼球摘除术适应症是视网膜母细胞瘤(n=1257, 82%;p < 0.001);中年人常见的眼球摘除术适应症是眼球萎缩或眼结核(n=163,39%;p < 0.001);老年人常见的眼球摘除术适应症是葡萄膜黑色素瘤(n=25,42%;p < 0.001)。近年来, 眼球萎缩/眼结核/疼痛性失明行眼球摘除术者 (1996年-2000年 33%, 2010年-2018年7%)和急性创伤行眼球摘除术者(1996年-2000年3%, 2010年-2018年<1%;p < 0.001)均呈现下降趋势。而眼内肿瘤行眼球摘除术者呈上升趋势, 其包括视网膜母细胞瘤(1996年-2000年 56%, 2010年-2018年 73%;p=0.01)和葡萄膜黑色素瘤(1996年-2000年3%, 2010年-2018年11%;p < 0.006)。结论:在亚洲印度地区人群中, 恶性肿瘤仍然是青年和老年患者行眼球摘除术最常见的适应症, 而对个性化眼球假体更好的晶状体形态的渴望是中老年人行眼球摘除术的主要指征。.
Identifiants
pubmed: 30315260
doi: 10.1038/s41433-018-0226-9
pii: 10.1038/s41433-018-0226-9
pmc: PMC6328534
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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