A new drug carrier with oxygen generation function for modulating tumor hypoxia microenvironment in cancer chemotherapy.
Allografts
Animals
Antibiotics, Antineoplastic
/ metabolism
Cell Line, Tumor
Combined Modality Therapy
Doxorubicin
/ metabolism
Drug Carriers
Drug Liberation
Female
Ferrosoferric Oxide
/ chemistry
Fibroblasts
/ cytology
Gold
/ chemistry
HeLa Cells
Humans
Hydrogen-Ion Concentration
Infrared Rays
Magnetic Fields
Mice
Nanoparticles
/ chemistry
Neoplasms, Experimental
Oxides
Oxygen
/ agonists
Reactive Oxygen Species
/ agonists
Silicon Dioxide
/ chemistry
Tumor Hypoxia
Uterine Cervical Neoplasms
/ metabolism
Au(2)O(3)
Chemotherapy
Drug release
Magnetic Fe(3)O(4)
Oxygen generation function
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
27
06
2018
revised:
01
10
2018
accepted:
03
10
2018
pubmed:
14
10
2018
medline:
26
3
2019
entrez:
14
10
2018
Statut:
ppublish
Résumé
Hypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrier (named as FeSiAuO) containing Fe
Identifiants
pubmed: 30316080
pii: S0927-7765(18)30703-3
doi: 10.1016/j.colsurfb.2018.10.008
pii:
doi:
Substances chimiques
Antibiotics, Antineoplastic
0
Drug Carriers
0
Oxides
0
Reactive Oxygen Species
0
Gold
7440-57-5
Silicon Dioxide
7631-86-9
Doxorubicin
80168379AG
Oxygen
S88TT14065
Ferrosoferric Oxide
XM0M87F357
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
335-345Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.