Is the hematocrit still an issue in quantitative dried blood spot analysis?
Alternative sampling
Dried blood spot
Hematocrit
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
30 Jan 2019
30 Jan 2019
Historique:
received:
26
07
2018
revised:
02
10
2018
accepted:
03
10
2018
pubmed:
15
10
2018
medline:
29
1
2019
entrez:
15
10
2018
Statut:
ppublish
Résumé
Hematocrit-related issues remain a major barrier for (regulatory) acceptance of the classical dried blood spot (DBS) analysis in the bioanalytical and clinical field. Lately, many attempts to cope with these issues have been made. Throughout this review, an overview is provided on new strategies that try to cope with this hematocrit effect (going from avoiding to minimizing), on methods estimating a DBS volume, and on methods estimating or measuring the hematocrit of a DBS. Although many successful strategies have been put forward, a combination of different technologies still provides the most complete solution. Therefore, further efforts and the availability of a straightforward guideline for analytical and clinical method validation should help to overcome the hurdles still associated with DBS sampling.
Identifiants
pubmed: 30317075
pii: S0731-7085(18)31723-0
doi: 10.1016/j.jpba.2018.10.010
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-196Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.