Incorporation of functionalized carbon nanotubes into hydrophobic drug crystals for enhancing aqueous dissolution.
Anti-Bacterial Agents
/ chemistry
Antifungal Agents
/ chemistry
Chemical Precipitation
Crystallization
Griseofulvin
/ chemistry
Humans
Hydrophobic and Hydrophilic Interactions
Nanotubes, Carbon
/ chemistry
Solubility
Solvents
/ chemistry
Sulfamethoxazole
/ chemistry
Technology, Pharmaceutical
/ methods
Water
/ chemistry
Bioavailability
Carbon nanotubes
Dissolution rate
Drug delivery
Hydrophobic drugs
Nanomedicine
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
06
06
2018
revised:
28
09
2018
accepted:
29
09
2018
pubmed:
15
10
2018
medline:
26
3
2019
entrez:
15
10
2018
Statut:
ppublish
Résumé
We present for the first time the direct incorporation of carboxylated carbon nanotubes (f-CNTs) into hydrophobic drug particles during their formation via anti-solvent precipitation. The approach was tested using two drugs namely antifungal agent Griseofulvin (GF) and antibiotic Sulfamethoxazole (SMZ) that had very different aqueous solubility. It was observed that the f-CNTs dispersed in the water served as nucleating sites for crystallization and were readily incorporated into the drug particles without altering crystal structure or other properties. The results showed that the hydrophilic f-CNTs dramatically enhanced dissolution rate for both drugs, and the time necessary to reach 80% dissolution (t
Identifiants
pubmed: 30317125
pii: S0927-7765(18)30694-5
doi: 10.1016/j.colsurfb.2018.09.080
pmc: PMC6292730
mid: NIHMS1509504
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Nanotubes, Carbon
0
Solvents
0
Water
059QF0KO0R
Griseofulvin
32HRV3E3D5
Sulfamethoxazole
JE42381TNV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
386-391Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES023209
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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