Ovarian cancer stem cell: A potential therapeutic target for overcoming multidrug resistance.
CSC markers
cancer stem cells
multidrug resistance
ovarian cancer
self-renewal
tumor-initiating cells
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
13
10
2017
accepted:
27
04
2018
pubmed:
15
10
2018
medline:
17
3
2020
entrez:
15
10
2018
Statut:
ppublish
Résumé
The cancer stem cell (CSC) model encompasses an advantageous paradigm that in recent decades provides a better elucidation for many important biological aspects of cancer initiation, progression, metastasis, and, more important, development of multidrug resistance (MDR). Such several other hematological malignancies and solid tumors and the identification and isolation of ovarian cancer stem cells (OV-CSCs) show that ovarian cancer also follows this hierarchical model. Gaining a better insight into CSC-mediated resistance holds promise for improving current ovarian cancer therapies and prolonging the survival of recurrent ovarian cancer patients in the future. Therefore, in this review, we will discuss some important mechanisms by which CSCs can escape chemotherapy, and then review the recent and growing body of evidence that supports the contribution of CSCs to MDR in ovarian cancer.
Substances chimiques
Antineoplastic Agents
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3238-3253Informations de copyright
© 2018 Wiley Periodicals, Inc.