Evidence for an unknown agent antigenically related to the hepatitis E virus in dairy cows in the United States.
bovine
cattle
hepatitis E virus (HEV)
neutralizing antibodies
seroprevalence
zoonotic transmission
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
07
09
2018
accepted:
11
10
2018
pubmed:
16
10
2018
medline:
18
3
2020
entrez:
16
10
2018
Statut:
ppublish
Résumé
Genotypes 3 and 4 hepatitis E virus (HEV) strains within the species Orthohepevirus A in the family Hepeviridae are zoonotic. Recently, a genotype 4 HEV was reportedly detected in fecal samples of cows, although independent confirmation is lacking. In this study, we first tested serum samples from 983 cows in different regions in the United States for the presence of immunoglobulin G (IgG) anti-HEV and found that 20.4% of cows were seropositive. The highest seroprevalence rate (68.4%) was from a herd in Georgia. In an attempt to genetically identify HEV in cattle, a prospective study was conducted in a known seropositive dairy herd by monitoring 10 newborn calves from birth to 6 months of age for evidence of HEV infection. At least 3 of the 10 calves seroconverted to IgG anti-HEV, and importantly the antibodies presented neutralized genotype 3 human HEV, thus, indicating the specificity of IgG anti-HEV in the cattle. However, our extensive attempts to identify HEV-related sequences in cattle using broad-spectrum reverse transcription-polymerase chain reaction assays and MiSeq deep-sequencing technology failed. The results suggest the existence of an agent antigenically related to HEV in cattle, although, contrary to published reports, we showed that the IgG recognizing HEV in cattle was not caused by HEV infection.
Identifiants
pubmed: 30318625
doi: 10.1002/jmv.25339
pmc: PMC6374170
mid: NIHMS993683
doi:
Substances chimiques
Hepatitis Antibodies
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
677-686Subventions
Organisme : NIH HHS
ID : T32 OD010430
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI074667
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050611
Pays : United States
Informations de copyright
© 2018 Wiley Periodicals, Inc.
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