Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers.
Atrophy
Axonal injury
Connectivity
Epileptogenesis
Inflammation
Magnetic resonance imaging (MRI)
Plasticity
Positron emission tomography (PET)
Vascular injury
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
03
08
2018
revised:
04
10
2018
accepted:
11
10
2018
pubmed:
16
10
2018
medline:
22
11
2019
entrez:
16
10
2018
Statut:
ppublish
Résumé
Posttraumatic epilepsy (PTE) is a major neurodegenerative disease accounting for 20% of symptomatic epilepsy cases. A long latent phase offers a potential window for prophylactic treatment strategies to prevent epilepsy onset, provided that the patients at risk can be identified. Some promising imaging biomarker candidates for posttraumatic epileptogenesis have been identified, but more are required to provide the specificity and sensitivity for accurate prediction. Experimental models and preclinical longitudinal, multimodal imaging studies allow follow-up of complex cascade of events initiated by traumatic brain injury, as well as monitoring of treatment effects. Preclinical imaging data from the posttraumatic brain are rich in information, yet examination of their specific relevance to epilepsy is lacking. Accumulating evidence from ongoing preclinical studies in TBI support insight into processes involved in epileptogenesis, e.g. inflammation and changes in functional and structural brain-wide connectivity. These efforts are likely to produce both new biomarkers and treatment targets for PTE.
Identifiants
pubmed: 30321600
pii: S0969-9961(18)30707-1
doi: 10.1016/j.nbd.2018.10.008
pmc: PMC6818714
mid: NIHMS1054724
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-85Subventions
Organisme : NICHD NIH HHS
ID : U54 HD087101
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS100064
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091222
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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