UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells.
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
21
06
2018
revised:
11
09
2018
accepted:
02
10
2018
pubmed:
17
10
2018
medline:
28
1
2020
entrez:
17
10
2018
Statut:
ppublish
Résumé
UNC-45A, a highly conserved member of the UCS (UNC45A/CRO1/SHE4P) protein family of cochaperones, plays an important role in regulating cytoskeletal-associated functions in invertebrates and mammalian cells, including cytokinesis, exocytosis, cell motility, and neuronal development. Here, for the first time, UNC-45A is demonstrated to function as a mitotic spindle-associated protein that destabilizes microtubules (MT) activity. Using
Identifiants
pubmed: 30322860
pii: 1541-7786.MCR-18-0670
doi: 10.1158/1541-7786.MCR-18-0670
pmc: PMC6359974
mid: NIHMS1509277
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Microtubule-Associated Proteins
0
UNC45A protein, human
0
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
370-383Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM103833
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM126974
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009138
Pays : United States
Informations de copyright
©2018 American Association for Cancer Research.
Références
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13916-21
pubmed: 26512117
J Biol Chem. 2008 May 9;283(19):13185-93
pubmed: 18326487
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9552-6
pubmed: 8105478
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1561-5
pubmed: 6103535
PLoS One. 2011;6(8):e23888
pubmed: 21909374
J Immunol. 2015 Nov 15;195(10):4760-70
pubmed: 26438524
Mol Biol Cell. 1999 Apr;10(4):947-59
pubmed: 10198049
Chem Biol. 1999 Mar;6(3):R65-9
pubmed: 10074470
Nature. 1979 Feb 22;277(5698):665-7
pubmed: 423966
Neuron. 2014 Dec 17;84(6):1240-57
pubmed: 25521379
Mol Biol Cell. 2017 May 15;28(10):1337-1346
pubmed: 28356421
Mol Cell Biol. 2006 Mar;26(5):1722-30
pubmed: 16478993
J Cell Sci. 2002 Nov 1;115(Pt 21):4013-23
pubmed: 12356907
Cancer Cell. 2005 Jan;7(1):51-63
pubmed: 15652749
Nat Rev Cancer. 2003 Jul;3(7):502-16
pubmed: 12835670
Curr Biol. 2005 Apr 26;15(8):724-31
pubmed: 15854904
Cancer Res. 2002 Apr 1;62(7):1935-8
pubmed: 11929805
J Cell Sci. 2012 Jun 1;125(Pt 11):2561-9
pubmed: 22595526
Subcell Biochem. 2015;78:133-52
pubmed: 25487020
Science. 2002 Jan 25;295(5555):669-71
pubmed: 11809970
Cancer Lett. 2015 Feb 1;357(1):114-120
pubmed: 25444911
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7176-E7184
pubmed: 27803321
J Cell Sci. 2016 Apr 1;129(7):1319-28
pubmed: 26869224
Dev Cell. 2012 Oct 16;23(4):729-44
pubmed: 23022035
CA Cancer J Clin. 2001 Jan-Feb;51(1):15-36
pubmed: 11577478
Curr Biol. 2000 Apr 6;10(7):397-400
pubmed: 10753748
Curr Biol. 2017 Dec 4;27(23):R1287-R1292
pubmed: 29207274
J Clin Oncol. 1992 Nov;10(11):1748-53
pubmed: 1357110
Cancer Cell. 2015 Jul 13;28(1):82-96
pubmed: 26096845
Cancer Res. 1987 May 1;47(9):2486-93
pubmed: 2882837
Mol Biol Cell. 2014 Sep 15;25(18):2677-81
pubmed: 25213191
Genes Dev. 2004 Apr 15;18(8):862-76
pubmed: 15078817
Cell Cycle. 2008 Jul 15;7(14):2146-56
pubmed: 18635958
Cell Motil Cytoskeleton. 2008 Aug;65(8):595-613
pubmed: 18481305
Annu Rev Cell Dev Biol. 2013;29:417-41
pubmed: 23875646
Am J Pathol. 2007 Nov;171(5):1640-9
pubmed: 17872978
J Cell Biol. 1998 Nov 30;143(5):1215-25
pubmed: 9832550
Clin Cancer Res. 2014 Jun 15;20(12):3174-86
pubmed: 24727327
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21382-7
pubmed: 21115842
Int Rev Cell Mol Biol. 2014;313:103-44
pubmed: 25376491
Nat Cell Biol. 2014 May;16(5):386-94
pubmed: 24914434
Curr Opin Cell Biol. 2010 Feb;22(1):96-103
pubmed: 19963362
J Cell Biol. 2017 Dec 4;216(12):4053-4072
pubmed: 29055011
Gynecol Oncol. 2015 Jul;138(1):181-9
pubmed: 25913133
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12390-5
pubmed: 25114250
Sci Transl Med. 2014 Mar 26;6(229):229ra43
pubmed: 24670687
J Clin Invest. 2012 Mar;122(3):844-58
pubmed: 22293177
J Mol Biol. 2011 Sep 23;412(3):365-78
pubmed: 21802425