Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer.
Animals
Antineoplastic Agents
/ pharmacology
Bridged-Ring Compounds
/ pharmacology
Calcium-Binding Proteins
/ metabolism
Cell Line, Tumor
Computational Biology
Disease Models, Animal
Disease Progression
Drug Resistance, Neoplasm
/ genetics
Eukaryotic Initiation Factor-4F
/ metabolism
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Silencing
Humans
Male
Mice
Prostatic Neoplasms
/ drug therapy
Protein Binding
RNA, Small Interfering
/ genetics
Tacrolimus Binding Proteins
/ metabolism
Taxoids
/ pharmacology
Transcriptome
Xenograft Model Antitumor Assays
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
01
03
2018
revised:
29
07
2018
accepted:
10
10
2018
pubmed:
17
10
2018
medline:
28
2
2020
entrez:
17
10
2018
Statut:
ppublish
Résumé
Targeted therapies that use the signaling pathways involved in prostate cancer are required to overcome chemoresistance and improve treatment outcomes for men. Molecular chaperones play a key role in the regulation of protein homeostasis and are potential targets for overcoming chemoresistance. We identified FKBP7, a prolyl-peptidyl isomerase overexpressed in docetaxel-resistant and in cabazitaxel-resistant prostate cancer cells. This is the first study to characterize the function of human FKBP7 and explore its role in cancer. We discovered that FKBP7 was upregulated in human prostate cancers and its expression correlated with the recurrence observed in patients receiving docetaxel. Targeting FKBP7 or the eIF4G-containing eIF4F translation initiation complex could be novel therapeutic strategies to eradicate taxane-resistant prostate cancer cells.
Identifiants
pubmed: 30322877
pii: 1078-0432.CCR-18-0704
doi: 10.1158/1078-0432.CCR-18-0704
doi:
Substances chimiques
Antineoplastic Agents
0
Bridged-Ring Compounds
0
Calcium-Binding Proteins
0
Eukaryotic Initiation Factor-4F
0
FKBP7 protein, human
0
RNA, Small Interfering
0
Taxoids
0
taxane
1605-68-1
Tacrolimus Binding Proteins
EC 5.2.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
710-723Informations de copyright
©2018 American Association for Cancer Research.