Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study.

Aged Carcinoma, Pancreatic Ductal / genetics Case-Control Studies Europe Female Genome-Wide Association Study Humans Lymphocytes / metabolism Male Middle Aged Pancreatic Neoplasms / genetics Polymorphism, Single Nucleotide Ribonucleoproteins / genetics Telomerase / genetics Telomere / metabolism Telomere Shortening / genetics
Mendelian randomization association genetic polymorphisms lymphocyte telomere length pancreatic ductal adenocarcinoma

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
15 03 2019
Historique:
received: 18 04 2018
revised: 12 09 2018
accepted: 13 09 2018
pubmed: 17 10 2018
medline: 7 6 2019
entrez: 17 10 2018
Statut: ppublish

Résumé

Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for several cancers. For pancreatic ductal adenocarcinoma (PDAC) consensus is lacking whether risk is associated with long or short telomeres. Mendelian randomization approaches have shown that a score built from SNPs associated with LTL could be used as a robust risk marker. We explored this approach in a large scale study within the PANcreatic Disease ReseArch (PANDoRA) consortium. We analyzed 10 SNPs (ZNF676-rs409627, TERT-rs2736100, CTC1-rs3027234, DHX35-rs6028466, PXK-rs6772228, NAF1-rs7675998, ZNF208-rs8105767, OBFC1-rs9420907, ACYP2-rs11125529 and TERC-rs10936599) alone and combined in a LTL genetic score ("teloscore", which explains 2.2% of the telomere variability) in relation to PDAC risk in 2,374 cases and 4,326 controls. We identified several associations with PDAC risk, among which the strongest were with the TERT-rs2736100 SNP (OR = 1.54; 95%CI 1.35-1.76; p = 1.54 × 10

Identifiants

DOI: 10.1002/ijc.31928 PMID: 30325019
pubmed: 30325019
doi: 10.1002/ijc.31928
doi:

Substances chimiques

NAF1 protein, human 0
Ribonucleoproteins 0
TERT protein, human EC 2.7.7.49
Telomerase EC 2.7.7.49

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1275-1283

Subventions

Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom

Informations de copyright

© 2018 UICC.

Auteurs

Daniele Campa (D)

Department of Biology, University of Pisa, Pisa, Italy.
ORCID: 0000-0003-3220-9944

Martina Matarazzi (M)

Department of Biology, University of Pisa, Pisa, Italy.
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

William Greenhalf (W)

Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom.

Maarten Bijlsma (M)

Medical Oncology, Academic Medical Centre, Amsterdam, The Netherlands.
ORCID: 0000-0001-6627-3229

Kai-Uwe Saum (KU)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Claudio Pasquali (C)

Pancreatic and Digestive Endocrine Surgery - Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, Padova, Italy.

Hanneke van Laarhoven (H)

Medical Oncology, Academic Medical Centre, Amsterdam, The Netherlands.

Andrea Szentesi (A)

Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
First Department of Medicine, University of Szeged, Szeged, Hungary.

Francesca Federici (F)

Oncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy.

Pavel Vodicka (P)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague, Czech Republic.
Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic.
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Niccola Funel (N)

Department of Surgery, Unit of Experimental Surgical Pathology, University of Pisa, Pisa, Italy.

Raffaele Pezzilli (R)

Pancreas Unit, Department of Digestive System, Sant'Orsola-Malpighi Hospital, Bologna, Italy.

H Bas Bueno-de-Mesquita (HB)

Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.
Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom.
Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Ludmila Vodickova (L)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague, Czech Republic.
Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic.
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Daniela Basso (D)

Department of Laboratory Medicine, University-Hospital of Padova, Padua, Italy.

Ofure Obazee (O)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Thilo Hackert (T)

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Pavel Soucek (P)

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
ORCID: 0000-0002-4294-6799

Katarina Cuk (K)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jörg Kaiser (J)

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Cosimo Sperti (C)

Third Surgical Clinic - Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, Padova, Italy.

Martin Lovecek (M)

Department of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.

Gabriele Capurso (G)

Digestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University, Rome, Italy.
PancreatoBiliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy.

Beatrice Mohelnikova-Duchonova (B)

Department of Oncology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

Kay-Tee Khaw (KT)

University of Cambridge School of Clinical Medicine Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom.

Anna-Katharina König (AK)

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Juozas Kupcinskas (J)

Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Rudolf Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0003-3751-3929

Franco Bambi (F)

Blood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Florence, Italy.

Livia Archibugi (L)

Digestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University, Rome, Italy.
PancreatoBiliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy.

Andrea Mambrini (A)

Oncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy.

Giulia Martina Cavestro (GM)

Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.

Stefano Landi (S)

Department of Biology, University of Pisa, Pisa, Italy.

Péter Hegyi (P)

Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
First Department of Medicine, University of Szeged, Szeged, Hungary.
MTA-SZTE Momentum Translational Gastroenterology Research Group, Szeged, Hungary.

Jakob R Izbicki (JR)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Domenica Gioffreda (D)

Division of Gastroenterology and Molecular Biology Lab, IRCCS Ospedale Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy.

Carlo Federico Zambon (CF)

Third Surgical Clinic - Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, Padova, Italy.

Francesca Tavano (F)

Division of Gastroenterology and Molecular Biology Lab, IRCCS Ospedale Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy.
ORCID: 0000-0002-8831-7349

Renata Talar-Wojnarowska (R)

Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.

Krzysztof Jamroziak (K)

Institute of Hematology and Transfusion Medicine, Warsaw, Poland.

Timothy J Key (TJ)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Gianfranco Delle Fave (GD)

Digestive and Liver Disease Unit, S. Andrea Hospital, 'Sapienza' University, Rome, Italy.

Oliver Strobel (O)

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Laimas Jonaitis (L)

Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Angelo Andriulli (A)

Division of Gastroenterology and Molecular Biology Lab, IRCCS Ospedale Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy.

Rita T Lawlor (RT)

ARC-NET, University and Hospital Trust of Verona, Verona, Italy.

Felice Pirozzi (F)

Division of Abdominal Surgery, IRCCS Ospedale Casa Sollievo Sofferenza, San Giovanni Rotondo, Italy.

Verena Katzke (V)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Chiara Valsuani (C)

Oncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy.

Yogesh K Vashist (YK)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Federico Canzian (F)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-4261-4583

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genetic determinants of telomere length and...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Genetic determinants of telomere length and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Genetic determinants of telomere length and...
questionsmedicales.fr › Régions géographiques › Europe › Genetic determinants of telomere length and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetic determinants of telomere length and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic determinants of telomere length and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Genetic determinants of telomere length and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic determinants of telomere length and...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Genetic determinants of telomere length and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genetic determinants of telomere length and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Genetic determinants of telomere length and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Telomerase › Genetic determinants of telomere length and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Genetic determinants of telomere length and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Raccourcissement des télomères › Genetic determinants of telomere length and...