Angiopoietin-1/Tie2 signaling pathway contributes to the therapeutic effect of thymosin β4 on diabetic peripheral neuropathy.
Angiopoietin-1
/ metabolism
Animals
Blood Glucose
/ drug effects
Body Weight
/ drug effects
Diabetes Mellitus, Experimental
/ complications
Diabetic Neuropathies
/ drug therapy
Mice
Mice, Transgenic
Nerve Fibers
/ drug effects
Receptor, TIE-2
/ antagonists & inhibitors
Sciatic Nerve
/ blood supply
Signal Transduction
/ drug effects
Thymosin
/ pharmacology
Anti-Tie2
Diabetic peripheral neuropathy
Mouse
Thymosin β4
Journal
Neuroscience research
ISSN: 1872-8111
Titre abrégé: Neurosci Res
Pays: Ireland
ID NLM: 8500749
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
10
08
2018
revised:
28
09
2018
accepted:
11
10
2018
pubmed:
17
10
2018
medline:
18
3
2020
entrez:
17
10
2018
Statut:
ppublish
Résumé
Angiopoietin-1 (Ang1) and its receptor Tie2 regulate vascular function. Our previous study demonstrated that thymosin beta 4 (Tβ4) ameliorates neurological function of diabetic peripheral neuropathy. Mechanisms underlying the therapeutic effect of Tβ4 on diabetic peripheral neuropathy have not been fully investigated. The present in vivo study investigated whether the Ang1/Tie2 signaling pathway is involved in Tβ4-improved neurovascular remodeling in diabetic peripheral neuropathy. Diabetic BKS. Cg-m+/+Lepr
Identifiants
pubmed: 30326249
pii: S0168-0102(18)30441-3
doi: 10.1016/j.neures.2018.10.005
pmc: PMC6462258
mid: NIHMS1509650
pii:
doi:
Substances chimiques
Angiopoietin-1
0
Angpt1 protein, mouse
0
Blood Glucose
0
thymosin beta(4)
549LM7U24W
Thymosin
61512-21-8
Receptor, TIE-2
EC 2.7.10.1
Tek protein, mouse
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-8Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK097519
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075084
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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