Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer.
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
30
04
2018
revised:
02
08
2018
accepted:
11
10
2018
pubmed:
20
10
2018
medline:
28
1
2020
entrez:
19
10
2018
Statut:
ppublish
Résumé
Resistance to standard therapy remains a major challenge in the treatment of pancreatic ductal adenocarcinoma (PDA). Although anti-VEGF therapy delays PDA progression, therapy-induced hypoxia results in a less differentiated mesenchymal-like tumor cell phenotype, which reinforces the need for effective companion therapies. COX-2 inhibition has been shown to promote tumor cell differentiation and improve standard therapy response in PDA. Here, we evaluate the efficacy of COX-2 inhibition and VEGF blockade in preclinical models of PDA.
Identifiants
pubmed: 30333153
pii: 1541-7786.MCR-18-0427
doi: 10.1158/1541-7786.MCR-18-0427
pmc: PMC6359969
mid: NIHMS1509935
doi:
Substances chimiques
Cyclooxygenase 2 Inhibitors
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
348-355Subventions
Organisme : NCI NIH HHS
ID : U54 CA210181
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA196033
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA136515
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA192381
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA138464
Pays : United States
Informations de copyright
©2018 American Association for Cancer Research.
Références
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Nat Rev Cancer. 2016 Apr;16(4):201-18
pubmed: 27009393
J Clin Invest. 2013 Aug;123(8):3190-200
pubmed: 23908119
Cancer Lett. 2017 Oct 28;407:57-65
pubmed: 28826722
Semin Oncol. 2004 Apr;31(2 Suppl 7):2-11
pubmed: 15179620
Clin Cancer Res. 2003 Mar;9(3):961-8
pubmed: 12631593
Annu Rev Immunol. 2006;24:99-146
pubmed: 16551245
J Clin Oncol. 2009 May 1;27(13):2231-7
pubmed: 19307500
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6
pubmed: 23045683
Cell Rep. 2016 Sep 27;17(1):233-248
pubmed: 27681434
J Gastroenterol Hepatol. 2014 Nov;29(11):1932-42
pubmed: 24909904
Nat Rev Immunol. 2010 Aug;10(8):554-67
pubmed: 20616810
J Clin Oncol. 2010 Aug 1;28(22):3617-22
pubmed: 20606091
Annu Rev Pathol. 2007;2:251-75
pubmed: 18039100
Gastroenterology. 1994 Oct;107(4):1183-8
pubmed: 7926468
Curr Drug Targets. 2011 Jun;12(7):1082-93
pubmed: 21443470
Cancer Lett. 2014 Feb 28;343(2):147-55
pubmed: 24141189
Int J Cell Biol. 2010;2010:215158
pubmed: 20339581
Sci Transl Med. 2014 Jun 25;6(242):242ra84
pubmed: 24964992
Clin Cancer Res. 2012 Sep 15;18(18):5031-42
pubmed: 22829202
Nat Med. 2014 Jun;20(6):607-15
pubmed: 24793239
Cancer Res. 2014 Feb 15;74(4):1032-44
pubmed: 24346431
CA Cancer J Clin. 2013 Sep;63(5):318-48
pubmed: 23856911
J Clin Invest. 2000 Jun;105(11):1589-94
pubmed: 10841517
Pharmacol Rep. 2010 Mar-Apr;62(2):233-44
pubmed: 20508278
Science. 2005 Jan 7;307(5706):58-62
pubmed: 15637262
Cancer Res. 2017 Aug 1;77(15):3982-3989
pubmed: 28428275
Nature. 2011 May 19;473(7347):298-307
pubmed: 21593862
Oncotarget. 2015 Mar 20;6(8):6341-58
pubmed: 25849942
Cancer Cell. 2009 Mar 3;15(3):220-31
pubmed: 19249680
Nat Med. 2015 Apr;21(4):327-34
pubmed: 25799228
Nat Med. 1999 Dec;5(12):1418-23
pubmed: 10581086
Cancer Cell. 2009 Mar 3;15(3):195-206
pubmed: 19249678
J Clin Oncol. 2013 Mar 20;31(9):1219-30
pubmed: 23401453
Cancer Lett. 2016 Oct 10;381(1):244-51
pubmed: 26723878
Crit Rev Oncol Hematol. 2007 Jan;61(1):52-69
pubmed: 16945549
Cancer Metastasis Rev. 2000;19(1-2):19-27
pubmed: 11191059
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
Carcinogenesis. 2012 Sep;33(9):1639-46
pubmed: 22678114
Invest Ophthalmol Vis Sci. 1998 Mar;39(3):581-91
pubmed: 9501870
N Engl J Med. 2008 May 8;358(19):2039-49
pubmed: 18463380
J Gastroenterol Hepatol. 2012 Mar;27(3):566-78
pubmed: 22097969
PLoS One. 2010 Aug 06;5(8):e12031
pubmed: 20700512
Genes Dev. 2003 Dec 15;17(24):3112-26
pubmed: 14681207
Nat Rev Cancer. 2010 Mar;10(3):181-93
pubmed: 20168319
Cancer Res. 2012 Jul 1;72(13):3125-30
pubmed: 22721837
Nat Rev Cancer. 2013 Dec;13(12):871-82
pubmed: 24263190
CA Cancer J Clin. 2017 Jan;67(1):7-30
pubmed: 28055103
Nature. 2015 Sep 10;525(7568):256-60
pubmed: 26331542