Hydroxylated Single-Walled Carbon Nanotubes Inhibit Aβ
Alzheimer’s disease
amyloid-β protein
cytotoxicity
hydroxylated single-walled carbon nanotubes
inhibitor
molecular dynamics simulation
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
16 01 2019
16 01 2019
Historique:
pubmed:
20
10
2018
medline:
19
2
2020
entrez:
19
10
2018
Statut:
ppublish
Résumé
The fibrillogenesis of amyloid-β protein (Aβ) is considered a crucial factor in the pathogenesis of Alzheimer's disease (AD). Hence, inhibiting Aβ fibrillogenesis is regarded as the primary therapeutic strategy for the prevention and treatment of AD. However, the development of effective inhibitors against Aβ fibrillogenesis has faced significant challenges. Previous studies have shown that pristine single-walled carbon nanotubes (SWNTs) can inhibit fibrillogenesis of some amyloid proteins. However, the poor dispersibility of SWNTs in an aqueous environment greatly hinders their inhibitory efficacy. Here, we examined the inhibitory activity of hydroxylated SWNTs (SWNT-OH) on the aggregation and cytotoxicity of Aβ
Identifiants
pubmed: 30335950
doi: 10.1021/acschemneuro.8b00441
doi:
Substances chimiques
Amyloid
0
Amyloid beta-Peptides
0
Nanotubes, Carbon
0
Peptide Fragments
0
Protective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM