Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.

Aged Alzheimer Disease / cerebrospinal fluid Amyloid beta-Peptides / cerebrospinal fluid Bile Acids and Salts / blood Biomarkers / cerebrospinal fluid Cognitive Dysfunction / cerebrospinal fluid Female Fluorodeoxyglucose F18 / metabolism Humans Magnetic Resonance Imaging Male Neuroimaging Positron-Emission Tomography Prospective Studies tau Proteins / cerebrospinal fluid
Alzheimer's disease Amyloid-β Bile acid Brain glucose metabolism CSF biomarkers Gut-liver-brain axis MRI Metabolomics PET

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
02 2019
Historique:
received: 20 03 2018
revised: 03 08 2018
accepted: 21 08 2018
pubmed: 20 10 2018
medline: 11 4 2020
entrez: 20 10 2018
Statut: ppublish

Résumé

Bile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests gut microbiota influence pathological features of Alzheimer's disease (AD) including neuroinflammation and amyloid-β deposition. Serum levels of 20 primary and secondary BA metabolites from the AD Neuroimaging Initiative (n = 1562) were measured using targeted metabolomic profiling. We assessed the association of BAs with the "A/T/N" (amyloid, tau, and neurodegeneration) biomarkers for AD: cerebrospinal fluid (CSF) biomarkers, atrophy (magnetic resonance imaging), and brain glucose metabolism ([ Of 23 BAs and relevant calculated ratios after quality control procedures, three BA signatures were associated with CSF Aβ This is the first study to show serum-based BA metabolites are associated with "A/T/N" AD biomarkers, providing further support for a role of BA pathways in AD pathophysiology. Prospective clinical observations and validation in model systems are needed to assess causality and specific mechanisms underlying this association.

Identifiants

DOI: 10.1016/j.jalz.2018.08.012 PMID: 30337152 PMC: PMC6454538
pubmed: 30337152
pii: S1552-5260(18)33521-0
doi: 10.1016/j.jalz.2018.08.012
pmc: PMC6454538
mid: NIHMS994005
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Bile Acids and Salts 0
Biomarkers 0
tau Proteins 0
Fluorodeoxyglucose F18 0Z5B2CJX4D

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

232-244

Subventions

Organisme : NIA NIH HHS
ID : R01 AG019771
Pays : United States
Organisme : NLM NIH HHS
ID : R00 LM011384
Pays : United States
Organisme : NLM NIH HHS
ID : K99 LM011384
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NINDS NIH HHS
ID : P50 NS053488
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM011360
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051550
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG046171
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046152
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010124
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG054936
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH098260
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB022574
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG049050
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM012535
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061359
Pays : United States

Informations de copyright

Copyright © 2018. Published by Elsevier Inc.

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Auteurs

Kwangsik Nho (K)

Department of Radiology and Imaging Sciences, Center for Computational Biology and Bioinformatics, and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.

Alexandra Kueider-Paisley (A)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.

Siamak MahmoudianDehkordi (S)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.

Matthias Arnold (M)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Shannon L Risacher (SL)

Department of Radiology and Imaging Sciences, Center for Computational Biology and Bioinformatics, and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.

Gregory Louie (G)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.

Colette Blach (C)

Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.

Rebecca Baillie (R)

Rosa & Co LLC, San Carlos, CA, USA.

Xianlin Han (X)

University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Gabi Kastenmüller (G)

Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.

Wei Jia (W)

University of Hawaii Cancer Center, Honolulu, HI, USA.

Guoxiang Xie (G)

University of Hawaii Cancer Center, Honolulu, HI, USA.

Shahzad Ahmad (S)

Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands.

Thomas Hankemeier (T)

Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, RA Leiden, the Netherlands.

Cornelia M van Duijn (CM)

Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands.

John Q Trojanowski (JQ)

Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Leslie M Shaw (LM)

Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Michael W Weiner (MW)

Center for Imaging of Neurodegenerative Diseases, Department of Radiology, San Francisco VA Medical Center/University of California San Francisco, San Francisco, CA, USA.

P Murali Doraiswamy (PM)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA.

Andrew J Saykin (AJ)

Department of Radiology and Imaging Sciences, Center for Computational Biology and Bioinformatics, and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.

Rima Kaddurah-Daouk (R)

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address: rima.kaddurahdaouk@duke.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Acides et sels biliaires › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Glucides › Désoses › Désoxyglucose › Fluorodésoxyglucose F18 › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Altered bile acid profile in mild cognitive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Altered bile acid profile in mild cognitive...