In vivo molecular imaging of neuroinflammation in Alzheimer's disease.
TSPO
Alzheimer's disease
magnetic resonance spectroscopy
neuroimaging
neuroinflammation
positron emission tomography
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
27
07
2018
revised:
24
09
2018
accepted:
27
09
2018
pubmed:
20
10
2018
medline:
19
3
2020
entrez:
20
10
2018
Statut:
ppublish
Résumé
It has become increasingly evident that neuroinflammation plays a critical role in the pathophysiology of Alzheimer's disease (AD) and other neurodegenerative disorders. Increased glial cell activation is consistently reported in both rodent models of AD and in AD patients. Moreover, recent genome wide association studies have revealed multiple genes associated with inflammation and immunity are significantly associated with an increased risk of AD development (e.g. TREM2). Non-invasive in vivo detection and tracking of neuroinflammation is necessary to enhance our understanding of the contribution of neuroinflammation to the initiation and progression of AD. Importantly, accurate methods of quantifying neuroinflammation may aid early diagnosis and serve as an output for therapeutic monitoring and disease management. This review details current in vivo imaging biomarkers of neuroinflammation being explored and summarizes both pre-clinical and clinical results from molecular imaging studies investigating the role of neuroinflammation in AD, with a focus on positron emission tomography and magnetic resonance spectroscopy (MRS).
Identifiants
pubmed: 30339715
doi: 10.1111/jnc.14615
pmc: PMC6563454
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
438-451Subventions
Organisme : BBSRC UK
ID : BB/F011350
Pays : International
Informations de copyright
© 2018 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
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